Susan A Charman

Affiliations

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Publications (15)

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.

Journal of medicinal chemistry

Avec: Daniel L Priebbenow , David J Leaver , Nghi Nguyen , Benjamin Cleary , H Rachel Lagiakos , Julie Sanchez , Lian Xue , Fei Huang , Yuxin Sun , Prashant Mujumdar , Ramesh Mudududdla , Swapna Varghese , Silvia Teguh , Susan A Charman , Karen L White , David M Shackleford , Kasiram Katneni , Matthew Cuellar , Jessica M Strasser , Jayme L Dahlin , Michael A Walters , Ian P Street , Brendon J Monahan , Kate E Jarman , Helene Jousset Sabroux , Hendrik Falk , Matthew C Chung , Stefan J Hermans , Natalie L Downer , Michael W Parker , Anne K Voss , Tim Thomas , Jonathan B Baell

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria.

Trends in parasitology

Avec: Carlo Giannangelo , Freya J I Fowkes , Julie A Simpson , Susan A Charman , Darren J Creek

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.

Journal of medicinal chemistry

Avec: Alexander Stoye , Annette Juillard , Arthur H Tang , Jennifer Legac , Jiri Gut , Karen L White , Susan A Charman , Philip J Rosenthal , Georges E R Grau , Nicholas H Hunt , Richard J Payne

Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides.

Antimicrobial agents and chemotherapy

Avec: Yiping Wang , Rupkatha Mukhopadhyay , Sujayita Roy , Arun Kapoor , Yu-Pin Su , Susan A Charman , Gong Chen , Jianbo Wu , Xiaofang Wang , Jonathan L Vennerstrom , Ravit Arav-Boger

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc

Science translational medicine

Avec: Stéphanie Braillard , Martine Keenan , Karen J Breese , Jacob Heppell , Michael Abbott , Rafiqul Islam , David M Shackleford , Kasiram Katneni , Elly Crighton , Gong Chen , Rahul Patil , Given Lee , Karen L White , Sandra Carvalho , Richard J Wall , Giulia Chemi , Fabio Zuccotto , Silvia González , Maria Marco , Julianna Deakyne , David Standing , Gino Brunori , Jonathan J Lyon , Pablo Castañeda-Casado , Isabel Camino , Maria S Martinez Martinez , Bilal Zulfiqar , Vicky M Avery , Pim-Bart Feijens , Natascha Van Pelt , An Matheeussen , Sarah Hendrickx , Louis Maes , Guy Caljon , Vanessa Yardley , Susan Wyllie , Susan A Charman , Eric Chatelain

Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.

Cell chemical biology

Avec: Aloysus Lawong , Suraksha Gahalawat , Sneha Ray , Nhi Ho , Yan Han , Kurt E Ward , Xiaoyi Deng , Zhe Chen , Ashwani Kumar , Chao Xing , Varun Hosangadi , Kate J Fairhurst , Kyuto Tashiro , Glen Liszczak , David M Shackleford , Kasiram Katneni , Gong Chen , Jessica Saunders , Elly Crighton , Arturo Casas , Joshua J Robinson , Leah S Imlay , Xiaoyu Zhang , Andrew Lemoff , Zhiyu Zhao , Iñigo Angulo-Barturen , María Belén Jiménez-Díaz , Sergio Wittlin , Simon F Campbell , David A Fidock , Benoît Laleu , Susan A Charman , Joseph M Ready , Margaret A Phillips

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.

Journal of medicinal chemistry

Avec: David J Leaver , Benjamin Cleary , Nghi Nguyen , Daniel L Priebbenow , H Rachel Lagiakos , Julie Sanchez , Lian Xue , Fei Huang , Yuxin Sun , Prashant Mujumdar , Ramesh Mudududdla , Swapna Varghese , Silvia Teguh , Susan A Charman , Karen L White , Kasiram Katneni , Matthew Cuellar , Jessica M Strasser , Jayme L Dahlin , Michael A Walters , Ian P Street , Brendon J Monahan , Kate E Jarman , Helene Jousset Sabroux , Hendrik Falk , Matthew C Chung , Stefan J Hermans , Michael W Parker , Tim Thomas , Jonathan B Baell

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.

Journal of medicinal chemistry

Avec: Lian Xue , Da-Hua Shi , Jitendra R Harjani , Fei Huang , Julia G Beveridge , Tamir Dingjan , Kung Ban , Sarah Diab , Sandra Duffy , Leonardo Lucantoni , Sabine Fletcher , Francis C K Chiu , Scott Blundell , Katherine Ellis , Stuart A Ralph , Grennady Wirjanata , Silvia Teguh , Rintis Noviyanti , Marina Chavchich , Darren Creek , Ric N Price , Jutta Marfurt , Susan A Charman , Matthew E Cuellar , Jessica M Strasser , Jayme L Dahlin , Michael A Walters , Michael D Edstein , Vicky M Avery , Jonathan B Baell

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.

Journal of medicinal chemistry

Avec: Sreekanth Kokkonda , Xiaoyi Deng , Karen L White , Farah El Mazouni , John White , David M Shackleford , Kasiram Katneni , Francis C K Chiu , Helena Barker , Jenna McLaren , Elly Crighton , Gong Chen , Inigo Angulo-Barturen , Maria Belen Jimenez-Diaz , Santiago Ferrer , Leticia Huertas-Valentin , Maria Santos Martinez-Martinez , Maria Jose Lafuente-Monasterio , Rajesh Chittimalla , Shatrughan P Shahi , Sergio Wittlin , David Waterson , Jeremy N Burrows , Dave Matthews , Diana Tomchick , Pradipsinh K Rathod , Michael J Palmer , Susan A Charman , Margaret A Phillips

Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.

The Journal of antimicrobial chemotherapy

Avec: Alexandra Probst , Cécile Häberli , Dionicio Siegel , Jianbo Huang , Seth Vigneron , Anh P Ta , Danielle E Skinner , Nelly El-Sakkary , Jeremiah D Momper , Jon Gangoiti , Yuxiang Dong , Jonathan L Vennerstrom , Susan A Charman , Conor R Caffrey , Jennifer Keiser

Synthetic Sansanmycin Analogues as Potent

Journal of medicinal chemistry

Avec: Wendy Tran , Ali S Kusay , Paige M E Hawkins , Chen-Yi Cheung , Gayathri Nagalingam , Venugopal Pujari , Daniel J Ford , Alexander Stoye , Jessica L Ochoa , Rebecca E Audette , Elinor Hortle , Stefan H Oehlers , Susan A Charman , Roger G Linington , Eric J Rubin , Christopher G Dowson , David I Roper , Dean C Crick , Thomas Balle , Gregory M Cook , Warwick J Britton , Richard J Payne

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as

ACS infectious diseases

Avec: Masanori Okaniwa , Akira Shibata , Atsuko Ochida , Yuichiro Akao , Karen L White , David M Shackleford , Sandra Duffy , Leonardo Lucantoni , Sumanta Dey , Josefine Striepen , Tomas Yeo , Sachel Mok , Anna Caroline C Aguiar , Angelika Sturm , Benigno Crespo , Laura M Sanz , Alisje Churchyard , Jake Baum , Dhelio B Pereira , Rafael V C Guido , Koen J Dechering , Sergio Wittlin , Anne-Catrin Uhlemann , David A Fidock , Jacquin C Niles , Vicky M Avery , Susan A Charman , Benoît Laleu

Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.

Bioorganic & medicinal chemistry

Avec: Benjamin J Buckley , Ashraf Aboelela , Hiwa Majed , Richard S Bujaroski , Karen L White , Andrew K Powell , Wen Wang , Kasiram Katneni , Jessica Saunders , David M Shackleford , Susan A Charman , Gregory M Cook , Michael J Kelso , Marie Ranson

Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones.

Malaria journal

Avec: Yizhe Chen , Fangyi Zhu , Jared Hammill , Gloria Holbrook , Lei Yang , Burgess Freeman , Karen L White , David M Shackleford , Kathleen G O'Loughlin , Susan A Charman , Jon C Mirsalis , R Kiplin Guy

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.

ACS infectious diseases

Avec: David M Shackleford , Francis C K Chiu , Kasiram Katneni , Scott Blundell , Jenna McLaren , Xiaofang Wang , Lin Zhou , Kamaraj Sriraghavan , André M Alker , Daniel Hunziker , Christian Scheurer , Qingjie Zhao , Yuxiang Dong , Jörg J Möhrle , Nada Abla , Hugues Matile , Sergio Wittlin , Jonathan L Vennerstrom , Susan A Charman

Réseau de co-auteurs

Karen L White 8 collaborations

David M Shackleford 8 collaborations

Kasiram Katneni 7 collaborations

Gong Chen 4 collaborations

Sergio Wittlin 4 collaborations

Lian Xue 3 collaborations

Fei Huang 3 collaborations

Silvia Teguh 3 collaborations

Jessica M Strasser 3 collaborations

Jayme L Dahlin 3 collaborations

Michael A Walters 3 collaborations

Jonathan B Baell 3 collaborations

Jonathan L Vennerstrom 3 collaborations

Elly Crighton 3 collaborations

Vicky M Avery 3 collaborations

Francis C K Chiu 3 collaborations

Daniel L Priebbenow 2 collaborations

David J Leaver 2 collaborations

Nghi Nguyen 2 collaborations

Benjamin Cleary 2 collaborations

H Rachel Lagiakos 2 collaborations

Julie Sanchez 2 collaborations

Yuxin Sun 2 collaborations

Prashant Mujumdar 2 collaborations

Ramesh Mudududdla 2 collaborations

Swapna Varghese 2 collaborations

Matthew Cuellar 2 collaborations

Ian P Street 2 collaborations

Brendon J Monahan 2 collaborations

Kate E Jarman 2 collaborations

Helene Jousset Sabroux 2 collaborations

Hendrik Falk 2 collaborations

Matthew C Chung 2 collaborations

Stefan J Hermans 2 collaborations

Michael W Parker 2 collaborations

Tim Thomas 2 collaborations

Alexander Stoye 2 collaborations

Richard J Payne 2 collaborations

Xiaofang Wang 2 collaborations

Xiaoyi Deng 2 collaborations

Jessica Saunders 2 collaborations

David A Fidock 2 collaborations

Benoît Laleu 2 collaborations

Margaret A Phillips 2 collaborations

Sandra Duffy 2 collaborations

Leonardo Lucantoni 2 collaborations

Scott Blundell 2 collaborations

Jenna McLaren 2 collaborations

Yuxiang Dong 2 collaborations

Gregory M Cook 2 collaborations

Natalie L Downer 1 collaboration

Anne K Voss 1 collaboration

Carlo Giannangelo 1 collaboration

Freya J I Fowkes 1 collaboration

Julie A Simpson 1 collaboration

Darren J Creek 1 collaboration

Annette Juillard 1 collaboration

Arthur H Tang 1 collaboration

Jennifer Legac 1 collaboration

Jiri Gut 1 collaboration

Philip J Rosenthal 1 collaboration

Georges E R Grau 1 collaboration

Nicholas H Hunt 1 collaboration

Yiping Wang 1 collaboration

Rupkatha Mukhopadhyay 1 collaboration

Sujayita Roy 1 collaboration

Arun Kapoor 1 collaboration

Yu-Pin Su 1 collaboration

Jianbo Wu 1 collaboration

Ravit Arav-Boger 1 collaboration

Stéphanie Braillard 1 collaboration

Martine Keenan 1 collaboration

Karen J Breese 1 collaboration

Jacob Heppell 1 collaboration

Michael Abbott 1 collaboration

Rafiqul Islam 1 collaboration

Rahul Patil 1 collaboration

Given Lee 1 collaboration

Sandra Carvalho 1 collaboration

Richard J Wall 1 collaboration

Giulia Chemi 1 collaboration

Fabio Zuccotto 1 collaboration

Silvia González 1 collaboration

Maria Marco 1 collaboration

Julianna Deakyne 1 collaboration

David Standing 1 collaboration

Gino Brunori 1 collaboration

Jonathan J Lyon 1 collaboration

Pablo Castañeda-Casado 1 collaboration

Isabel Camino 1 collaboration

Maria S Martinez Martinez 1 collaboration

Bilal Zulfiqar 1 collaboration

Pim-Bart Feijens 1 collaboration

Natascha Van Pelt 1 collaboration

An Matheeussen 1 collaboration

Sarah Hendrickx 1 collaboration

Louis Maes 1 collaboration

Guy Caljon 1 collaboration

Vanessa Yardley 1 collaboration

Susan Wyllie 1 collaboration

Eric Chatelain 1 collaboration

Aloysus Lawong 1 collaboration

Suraksha Gahalawat 1 collaboration

Sneha Ray 1 collaboration

Nhi Ho 1 collaboration

Yan Han 1 collaboration

Kurt E Ward 1 collaboration

Zhe Chen 1 collaboration

Ashwani Kumar 1 collaboration

Chao Xing 1 collaboration

Varun Hosangadi 1 collaboration

Kate J Fairhurst 1 collaboration

Kyuto Tashiro 1 collaboration

Glen Liszczak 1 collaboration

Arturo Casas 1 collaboration

Joshua J Robinson 1 collaboration

Leah S Imlay 1 collaboration

Xiaoyu Zhang 1 collaboration

Andrew Lemoff 1 collaboration

Zhiyu Zhao 1 collaboration

Iñigo Angulo-Barturen 1 collaboration

María Belén Jiménez-Díaz 1 collaboration

Simon F Campbell 1 collaboration

Joseph M Ready 1 collaboration

Da-Hua Shi 1 collaboration

Jitendra R Harjani 1 collaboration

Julia G Beveridge 1 collaboration

Tamir Dingjan 1 collaboration

Kung Ban 1 collaboration

Sarah Diab 1 collaboration

Sabine Fletcher 1 collaboration

Katherine Ellis 1 collaboration

Stuart A Ralph 1 collaboration

Grennady Wirjanata 1 collaboration

Rintis Noviyanti 1 collaboration

Marina Chavchich 1 collaboration

Darren Creek 1 collaboration

Ric N Price 1 collaboration

Jutta Marfurt 1 collaboration

Matthew E Cuellar 1 collaboration

Michael D Edstein 1 collaboration

Sreekanth Kokkonda 1 collaboration

Farah El Mazouni 1 collaboration

John White 1 collaboration

Helena Barker 1 collaboration

Inigo Angulo-Barturen 1 collaboration

Maria Belen Jimenez-Diaz 1 collaboration

Santiago Ferrer 1 collaboration

Leticia Huertas-Valentin 1 collaboration

Maria Santos Martinez-Martinez 1 collaboration

Maria Jose Lafuente-Monasterio 1 collaboration

Rajesh Chittimalla 1 collaboration

Shatrughan P Shahi 1 collaboration

David Waterson 1 collaboration

Jeremy N Burrows 1 collaboration

Dave Matthews 1 collaboration

Diana Tomchick 1 collaboration

Pradipsinh K Rathod 1 collaboration

Michael J Palmer 1 collaboration

Alexandra Probst 1 collaboration

Cécile Häberli 1 collaboration

Dionicio Siegel 1 collaboration

Jianbo Huang 1 collaboration

Seth Vigneron 1 collaboration

Anh P Ta 1 collaboration

Danielle E Skinner 1 collaboration

Nelly El-Sakkary 1 collaboration

Jeremiah D Momper 1 collaboration

Jon Gangoiti 1 collaboration

Conor R Caffrey 1 collaboration

Jennifer Keiser 1 collaboration

Wendy Tran 1 collaboration

Ali S Kusay 1 collaboration

Paige M E Hawkins 1 collaboration

Chen-Yi Cheung 1 collaboration

Gayathri Nagalingam 1 collaboration

Venugopal Pujari 1 collaboration

Daniel J Ford 1 collaboration

Jessica L Ochoa 1 collaboration

Rebecca E Audette 1 collaboration

Elinor Hortle 1 collaboration

Stefan H Oehlers 1 collaboration

Roger G Linington 1 collaboration

Eric J Rubin 1 collaboration

Christopher G Dowson 1 collaboration

David I Roper 1 collaboration

Dean C Crick 1 collaboration

Thomas Balle 1 collaboration

Warwick J Britton 1 collaboration

Masanori Okaniwa 1 collaboration

Akira Shibata 1 collaboration

Atsuko Ochida 1 collaboration

Yuichiro Akao 1 collaboration

Sumanta Dey 1 collaboration

Josefine Striepen 1 collaboration

Tomas Yeo 1 collaboration

Sachel Mok 1 collaboration

Anna Caroline C Aguiar 1 collaboration

Angelika Sturm 1 collaboration

Benigno Crespo 1 collaboration

Laura M Sanz 1 collaboration

Alisje Churchyard 1 collaboration

Jake Baum 1 collaboration

Dhelio B Pereira 1 collaboration

Rafael V C Guido 1 collaboration

Koen J Dechering 1 collaboration

Anne-Catrin Uhlemann 1 collaboration

Jacquin C Niles 1 collaboration

Benjamin J Buckley 1 collaboration

Ashraf Aboelela 1 collaboration

Hiwa Majed 1 collaboration

Richard S Bujaroski 1 collaboration

Andrew K Powell 1 collaboration

Wen Wang 1 collaboration

Michael J Kelso 1 collaboration

Marie Ranson 1 collaboration

Yizhe Chen 1 collaboration

Fangyi Zhu 1 collaboration

Jared Hammill 1 collaboration

Gloria Holbrook 1 collaboration

Lei Yang 1 collaboration

Burgess Freeman 1 collaboration

Kathleen G O'Loughlin 1 collaboration

Jon C Mirsalis 1 collaboration

R Kiplin Guy 1 collaboration

Lin Zhou 1 collaboration

Kamaraj Sriraghavan 1 collaboration

André M Alker 1 collaboration

Daniel Hunziker 1 collaboration

Christian Scheurer 1 collaboration

Qingjie Zhao 1 collaboration

Jörg J Möhrle 1 collaboration

Nada Abla 1 collaboration

Hugues Matile 1 collaboration