Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as
PRS
Plasmodium
malaria
prolyl-tRNA synthetase
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
11 06 2021
11 06 2021
Historique:
pubmed:
1
5
2021
medline:
24
6
2021
entrez:
30
4
2021
Statut:
ppublish
Résumé
Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set of PRS ATP-site binders, initially designed for human indications, led to identification of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives representing a novel antimalarial scaffold. Evidence designates cytoplasmic PRS as the drug target. The frontrunner
Identifiants
pubmed: 33929818
doi: 10.1021/acsinfecdis.1c00020
pmc: PMC8204304
doi:
Substances chimiques
Antimalarials
0
Amino Acyl-tRNA Synthetases
EC 6.1.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1680-1689Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100993/B/13/Z
Pays : United Kingdom
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