Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.

Amiloride / analogs & derivatives Animals Antineoplastic Agents / chemical synthesis Caco-2 Cells Drug Screening Assays, Antitumor Female Humans Male Mice, Inbred BALB C Microsomes, Liver / drug effects Molecular Structure Rats, Sprague-Dawley Structure-Activity Relationship
Amiloride Antimetastatic Cancer Lead optimization Metastasis SOSA Selective optimization of side activity Urokinase uPA

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
01 05 2021
Historique:
received: 26 11 2020
revised: 10 03 2021
accepted: 12 03 2021
pubmed: 3 4 2021
medline: 25 9 2021
entrez: 2 4 2021
Statut: ppublish

Résumé

The K

Identifiants

DOI: 10.1016/j.bmc.2021.116116 PMID: 33799173
pubmed: 33799173
pii: S0968-0896(21)00124-3
doi: 10.1016/j.bmc.2021.116116
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Amiloride 7DZO8EB0Z3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116116

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Benjamin J Buckley (BJ)

Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522, Australia; Molecular Horizons, University of Wollongong, NSW 2522, Australia; CONCERT-Translational Cancer Research Centre, NSW 2750, Australia. Electronic address: bbuckley@uow.edu.au.

Ashraf Aboelela (A)

School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522, Australia; Molecular Horizons, University of Wollongong, NSW 2522, Australia.

Hiwa Majed (H)

School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522, Australia; Molecular Horizons, University of Wollongong, NSW 2522, Australia.

Richard S Bujaroski (RS)

School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522, Australia; Molecular Horizons, University of Wollongong, NSW 2522, Australia.

Karen L White (KL)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052, Australia.

Andrew K Powell (AK)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052, Australia.

Wen Wang (W)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052, Australia.

Kasiram Katneni (K)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052, Australia.

Jessica Saunders (J)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052, Australia.

David M Shackleford (DM)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052, Australia.

Susan A Charman (SA)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052, Australia.

Gregory M Cook (GM)

Department of Microbiology and Immunology, University of Otago, Otago 9016, New Zealand.

Michael J Kelso (MJ)

Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522, Australia; Molecular Horizons, University of Wollongong, NSW 2522, Australia.

Marie Ranson (M)

Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522, Australia; Molecular Horizons, University of Wollongong, NSW 2522, Australia; CONCERT-Translational Cancer Research Centre, NSW 2750, Australia.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrazines › Amiloride › Systematic evaluation of structure-property...
questionsmedicales.fr › Eucaryotes › Animaux › Systematic evaluation of structure-property...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Systematic evaluation of structure-property...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Systematic evaluation of structure-property...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Systematic evaluation of structure-property...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Systematic evaluation of structure-property...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Systematic evaluation of structure-property...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Systematic evaluation of structure-property...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Systematic evaluation of structure-property...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Systematic evaluation of structure-property...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Systematic evaluation of structure-property...