First Long-term Oncologic Results of the ALPPS Procedure in a Large Cohort of Patients With Colorectal Liver Metastases.


Journal

Annals of surgery
ISSN: 1528-1140
Titre abrégé: Ann Surg
Pays: United States
ID NLM: 0372354

Informations de publication

Date de publication:
11 2020
Historique:
pubmed: 25 8 2020
medline: 11 11 2020
entrez: 25 8 2020
Statut: ppublish

Résumé

To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients with colorectal liver metastases (CRLM) undergoing ALPPS. ALPPS is a two-stage hepatectomy variant that increases resection rates and R0 resection rates in patients with primarily unresectable CRLM as evidenced in a recent randomized controlled trial. Long-term oncologic results, however, are lacking. Cases in- and outside the International ALPPS Registry were collected and completed by direct contacts to ALPPS centers to secure a comprehensive cohort. Overall, cancer-specific (CSS), and recurrence-free (RFS) survivals were analyzed along with independent risk factors using Cox-regression analysis. The cohort included 510 patients from 22 ALPPS centers over a 10-year period. Ninety-day mortality was 4.9% and median overall survival, CSS, and RFS were 39, 42, and 15 months, respectively. The median follow-up time was 38 months (95% confidence interval 32-43 months). Multivariate analysis identified tumor-characteristics (primary T4, right colon), biological features (K/N-RAS status), and response to chemotherapy (Response Evaluation Criteria in Solid Tumors) as independent predictors of CSS. Traditional factors such as size of metastases, uni versus bilobar involvement, and liver-first approach were not predictive. When hepatic recurrences after ALPPS was amenable to surgical/ablative treatment, median CSS was significantly superior compared to chemotherapy alone (56 vs 30 months, P < 0.001). This large cohort provides the first evidence that patients with primarily unresectable CRLM treated by ALPPS have not only low perioperative mortality, but achieve appealing long-term oncologic outcome especially those with favorable tumor biology and good response to chemotherapy.

Sections du résumé

OBJECTIVES
To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients with colorectal liver metastases (CRLM) undergoing ALPPS.
BACKGROUND
ALPPS is a two-stage hepatectomy variant that increases resection rates and R0 resection rates in patients with primarily unresectable CRLM as evidenced in a recent randomized controlled trial. Long-term oncologic results, however, are lacking.
METHODS
Cases in- and outside the International ALPPS Registry were collected and completed by direct contacts to ALPPS centers to secure a comprehensive cohort. Overall, cancer-specific (CSS), and recurrence-free (RFS) survivals were analyzed along with independent risk factors using Cox-regression analysis.
RESULTS
The cohort included 510 patients from 22 ALPPS centers over a 10-year period. Ninety-day mortality was 4.9% and median overall survival, CSS, and RFS were 39, 42, and 15 months, respectively. The median follow-up time was 38 months (95% confidence interval 32-43 months). Multivariate analysis identified tumor-characteristics (primary T4, right colon), biological features (K/N-RAS status), and response to chemotherapy (Response Evaluation Criteria in Solid Tumors) as independent predictors of CSS. Traditional factors such as size of metastases, uni versus bilobar involvement, and liver-first approach were not predictive. When hepatic recurrences after ALPPS was amenable to surgical/ablative treatment, median CSS was significantly superior compared to chemotherapy alone (56 vs 30 months, P < 0.001).
CONCLUSIONS
This large cohort provides the first evidence that patients with primarily unresectable CRLM treated by ALPPS have not only low perioperative mortality, but achieve appealing long-term oncologic outcome especially those with favorable tumor biology and good response to chemotherapy.

Identifiants

pubmed: 32833765
doi: 10.1097/SLA.0000000000004330
pii: 00000658-202011000-00019
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

793-800

Références

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Auteurs

Henrik Petrowsky (H)

Swiss HPB and Transplantation Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland.

Michael Linecker (M)

Swiss HPB and Transplantation Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland.

Dimitri A Raptis (DA)

Department of HPB- and Liver Transplantation Surgery, University College London, Royal Free Hospitals, London, UK.

Christoph Kuemmerli (C)

Swiss HPB and Transplantation Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland.

Ralph Fritsch (R)

Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.

Onur E Kirimker (OE)

Department of Surgery, Ankara University, Ankara, Turkey.

Deniz Balci (D)

Department of Surgery, Ankara University, Ankara, Turkey.

Francesca Ratti (F)

Hepatobiliary Surgery Division, Department of Surgery, IRCCS San Raffaele Hospital, School of Medicine, Milan, Italy.

Luca Aldrighetti (L)

Hepatobiliary Surgery Division, Department of Surgery, IRCCS San Raffaele Hospital, School of Medicine, Milan, Italy.

Sergey Voskanyan (S)

Department of Surgery, A.I. Burnazyan FMBC Russian State Scientific Center of FMBA, Moscow, Russia.

Federico Tomassini (F)

Department of Human Structure and Repair, Ghent University Faculty of Medicine, Ghent, Belgium.

Roberto I Troisi (RI)

Department of Human Structure and Repair, Ghent University Faculty of Medicine, Ghent, Belgium.
Department of Clinical Medicine and Surgery, Division of HPB, Minimally Invasive and Robotic Surgery, Federico II University Hospital Naples, Naples, Italy.

Jan Bednarsch (J)

Department of General, Visceral and Transplantation Surgery, University Hospital Aachen, RWTH Aachen, Germany.

Georg Lurje (G)

Department of General, Visceral and Transplantation Surgery, University Hospital Aachen, RWTH Aachen, Germany.
Department of Surgery, Charité Universitätsmedizin Berlin, Campus Charité Mitte and Campus Virchow Klinikum, Berlin, Germany.

Mohammad-Hossein Fard-Aghaie (MH)

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Asklepios Hospital Barmbek, Hamburg, Germany.
Semmelweis University Budapest, Campus Hamburg, Hamburg, Germany.

Tim Reese (T)

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Asklepios Hospital Barmbek, Hamburg, Germany.
Semmelweis University Budapest, Campus Hamburg, Hamburg, Germany.

Karl J Oldhafer (KJ)

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Asklepios Hospital Barmbek, Hamburg, Germany.
Semmelweis University Budapest, Campus Hamburg, Hamburg, Germany.

Omid Ghamarnejad (O)

Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Arianeb Mehrabi (A)

Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Mauro E Tun Abraham (MET)

Department of Surgery, Division of HPB Surgery and Liver Transplantation, London Health Sciences Centre, London, Ontario, Canada.

Stéphanie Truant (S)

Department of Digestive Surgery and Transplantation, University Hospital, Lille, France.

Francois-René Pruvot (FR)

Department of Digestive Surgery and Transplantation, University Hospital, Lille, France.

Emir Hoti (E)

Department of Hepatobiliary and Liver Transplant Surgery, St. Vincents University Hospital, Dublin, Ireland.

Patryk Kambakamba (P)

Department of Hepatobiliary and Liver Transplant Surgery, St. Vincents University Hospital, Dublin, Ireland.

Ivan Capobianco (I)

Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Germany.

Silvio Nadalin (S)

Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Germany.

Eduardo S M Fernandes (ESM)

Department of General Surgery and Transplantation, Hospital Adventista Silvestre, and Department of Surgery, Faculty of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Surgery, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.

Philipp Kron (P)

Swiss HPB and Transplantation Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland.
HPB and Transplant Unit, St. James's University Hospital, Leeds, UK.

Peter Lodge (P)

HPB and Transplant Unit, St. James's University Hospital, Leeds, UK.

Pim B Olthof (PB)

Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Thomas van Gulik (T)

Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Carlos Castro-Benitez (C)

Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif, France.

René Adam (R)

Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif, France.

Marcel Autran Machado (MA)

Department of Surgery, University of São Paulo, São Paulo, Brazil.

Martin Teutsch (M)

Department of Hepatobiliary Surgery and Transplantation University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Jun Li (J)

Department of Hepatobiliary Surgery and Transplantation University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Marcus N Scherer (MN)

Department of Surgery and Transplantation, University Hospital Regensburg, Regensburg, Germany.

Hans J Schlitt (HJ)

Department of Surgery and Transplantation, University Hospital Regensburg, Regensburg, Germany.

Victoria Ardiles (V)

Department of Surgery, Division of HPB Surgery, Liver Transplant Unit, Italian Hospital of Buenos Aires, Buenos Aires, Argentina.

Eduardo de Santibañes (E)

Department of Surgery, Division of HPB Surgery, Liver Transplant Unit, Italian Hospital of Buenos Aires, Buenos Aires, Argentina.

Roberto Brusadin (R)

Department of Surgery and Liver and Pancreas Transplantation, Virgen de la Arrixaca Clinic and University Hospital and IMIB, Murcia, Spain.

Victor Lopez-Lopez (V)

Department of Surgery and Liver and Pancreas Transplantation, Virgen de la Arrixaca Clinic and University Hospital and IMIB, Murcia, Spain.

Ricardo Robles-Campos (R)

Department of Surgery and Liver and Pancreas Transplantation, Virgen de la Arrixaca Clinic and University Hospital and IMIB, Murcia, Spain.

Massimo Malagó (M)

Department of HPB- and Liver Transplantation Surgery, University College London, Royal Free Hospitals, London, UK.

Roberto Hernandez-Alejandro (R)

Department of Surgery, Division of HPB Surgery and Liver Transplantation, London Health Sciences Centre, London, Ontario, Canada.
Division of Transplantation, Hepatobiliary Surgery, University of Rochester, Rochester, New York.

Pierre-Alain Clavien (PA)

Swiss HPB and Transplantation Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland.

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