Cancer neoantigen: Boosting immunotherapy.

Animals Antigens, Neoplasm / genetics Cancer Vaccines / administration & dosage Humans Immunotherapy / methods Neoplasms / genetics Precision Medicine / methods
Immunotherapy Melanoma Neoantigen Personalized vaccine Tumor mutational burden

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 10 07 2020
revised: 13 08 2020
accepted: 16 08 2020
pubmed: 25 8 2020
medline: 18 2 2021
entrez: 25 8 2020
Statut: ppublish

Résumé

Tumor neoantigen has a high degree of immunogenicity. As one of the emerging methods of tumor immunotherapy, the vaccine developed against it has served to clinical trials of various solid tumors, especially in the treatment of melanoma. Currently, a variety of immunotherapy methods have been applied to the treatment of the tumor. However, other therapeutic methods have the disadvantages of low specificity and prominent side effects. Treatments require tumor antigen with higher immunogenicity as the target of immune attack. This review will recommend the identification of neoantigen, the influencing factors of neoantigen, and the application of personalized vaccines for neoantigen in metastatic tumors such as malignant melanoma.

Identifiants

DOI: 10.1016/j.biopha.2020.110640 PMID: 32836075
pubmed: 32836075
pii: S0753-3322(20)30833-7
doi: 10.1016/j.biopha.2020.110640
pii:
doi:

Substances chimiques

Antigens, Neoplasm 0
Cancer Vaccines 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

110640

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Auteurs

Peijia Xu (P)

Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524023, China; The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang, 524023, China.

Haiqing Luo (H)

Cancer Center, Affiliated Hospital, Guangdong Medical University, Zhanjiang, 524023, China.

Ying Kong (Y)

Department of Clinical Laboratory, Hubei No. 3 People's Hospital of Jianghan University, Wuhan, 430033, China.

Wing-Fu Lai (WF)

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China; School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China. Electronic address: rori0610@graduate.hku.hk.

Liao Cui (L)

Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524023, China. Electronic address: cuiliao@163.com.

Xiao Zhu (X)

Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524023, China; The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang, 524023, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang, 524023, China. Electronic address: xzhu@gdmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cancer neoantigen: Boosting immunotherapy.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › Cancer neoantigen: Boosting immunotherapy.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins anticancéreux › Cancer neoantigen: Boosting immunotherapy.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cancer neoantigen: Boosting immunotherapy.
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Cancer neoantigen: Boosting immunotherapy.
questionsmedicales.fr › Tumeurs › Cancer neoantigen: Boosting immunotherapy.
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Cancer neoantigen: Boosting immunotherapy.