Influences of affective context on amygdala functional connectivity during cognitive control from adolescence through adulthood.
Adolescence
Affect
Antisaccade
Background connectivity
Cognitive control
fMRI
Journal
Developmental cognitive neuroscience
ISSN: 1878-9307
Titre abrégé: Dev Cogn Neurosci
Pays: Netherlands
ID NLM: 101541838
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
10
01
2020
revised:
11
06
2020
accepted:
04
08
2020
pubmed:
25
8
2020
medline:
16
12
2020
entrez:
25
8
2020
Statut:
ppublish
Résumé
Emotion processing is believed to dominate over other brain functions during adolescence, including inhibitory control. However, few studies have examined the neural underpinnings of affective states during cognitive control. Here, we characterized the brain in an affective state by cross-sectionally assessing age-related changes in amygdala background connectivity during an affective inhibitory control task. Participants completed an antisaccade (AS) fMRI task while affective auditory stimuli were presented, and a 5-minute resting state scan. Results showed that while adolescents reported similar arousal levels across emotional conditions, adults perceived negative sounds to be more "arousing" and performed better than adolescents in negative trials. Amygdala background connectivity showed age-related increases with brain regions related to attention and executive control, which were not evident during resting state. Together, results suggest that amygdala connectivity within an affective context is fairly low in mid-adolescence but much stronger in adulthood, supporting age-related improvements in inhibitory control within an affective state. These findings suggest limitations during adolescence in differentiating between the arousing effects of various emotions, potentially undermining the ability to optimally engage inhibitory control. Furthermore, the age-related fMRI findings suggest that low amygdala connectivity to brain areas involved in executive control may underlie these limited abilities during adolescence.
Identifiants
pubmed: 32836077
pii: S1878-9293(20)30084-0
doi: 10.1016/j.dcn.2020.100836
pmc: PMC7451790
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
100836Subventions
Organisme : NIMH NIH HHS
ID : K01 MH112774
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH067924
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
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