The impact of intensity-modulated radiation treatment on dento-alveolar microvasculature in pharyngeal cancer implant patients.
dental implants
head and neck cancer
intensity-modulated radiation treatment
microvasculature
osteoradionecrosis
Journal
Journal of oral rehabilitation
ISSN: 1365-2842
Titre abrégé: J Oral Rehabil
Pays: England
ID NLM: 0433604
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
25
04
2020
revised:
09
07
2020
accepted:
29
07
2020
pubmed:
26
8
2020
medline:
15
12
2020
entrez:
26
8
2020
Statut:
ppublish
Résumé
Dental rehabilitation post-radiotherapy often requires the consideration of dental implants. However, these are tentatively prescribed due to the concern of hypovascularisation and possible osteoradionecrosis. Hence, the current study assessed the microvasculature of the dento-alveolar bone at implant sites taking into consideration the exact radiotherapy dose received to the region. Bone cores were taken from nine patients during implant treatment and compared to nine control patients. Specimens were stained using CD31 and digitalised using a high-resolution scanner for qualitative and quantitative assessment of the microvasculature. Monaco A total of 23 bone cores were retrieved for analysis. The cohort had a D Intensity-modulated radiotherapy doses above 30 Gy identified reduction in microvasculature which is a lower threshold than previously accepted. In pharyngeal cancer patients' doses to the jaw bones often exceed this threshold. Coupled with favourable survival in certain oropharyngeal and nasopharyngeal cancer, dental rehabilitation via implants provides a significant clinical challenge.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1411-1421Subventions
Organisme : Royal College of Surgeons of England
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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