New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma.
ETS and Krüppel transcription factors
Gain-of-function mutation
Gliomas
TERT
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
25 08 2020
25 08 2020
Historique:
received:
04
06
2020
accepted:
12
08
2020
entrez:
27
8
2020
pubmed:
28
8
2020
medline:
1
6
2021
Statut:
epublish
Résumé
The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. In human tumors, ectopic TERT reactivation, most frequently due to hotspot mutations in the promoter region (TERTp), i.e. c.1-124 C > T, c.1-146 C > T, confers a proliferative advantage to neoplastic cells. In gliomas, TERTp mutations (TERTp
Identifiants
pubmed: 32843091
doi: 10.1186/s40478-020-01022-4
pii: 10.1186/s40478-020-01022-4
pmc: PMC7445914
doi:
Substances chimiques
TERT protein, human
EC 2.7.7.49
Telomerase
EC 2.7.7.49
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
145Références
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