Reward-predictive cues elicit excessive reward seeking in adolescent rats.
Adolescence
Impulse control
Motivation
Pavlovian-instrumental transfer
Rats
Reward
Journal
Developmental cognitive neuroscience
ISSN: 1878-9307
Titre abrégé: Dev Cogn Neurosci
Pays: Netherlands
ID NLM: 101541838
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
15
04
2020
revised:
03
07
2020
accepted:
12
08
2020
pubmed:
28
8
2020
medline:
16
12
2020
entrez:
27
8
2020
Statut:
ppublish
Résumé
Impulsive behavior during adolescence may stem from developmental imbalances between motivational and cognitive-control systems, producing greater urges to pursue reward and weakened capacities to inhibit such actions. Here, we developed a Pavlovian-instrumental transfer (PIT) protocol to assay rats' ability to suppress cue-motivated reward seeking based on changes in reward expectancy. Traditionally, PIT studies focus on how reward-predictive cues motivate instrumental reward-seeking behavior (lever pressing). However, cues signaling imminent reward delivery also elicit countervailing focal-search responses (food-port entry). We first examined how reward expectancy (cue-reward probability) influences expression of these competing behaviors. Adult male rats increased rates of lever pressing when presented with cues signaling lower probabilities of reward but focused their activity at the food cup on trials with cues that signaled higher probabilities of reward. We then compared adolescent and adult male rats in their responsivity to cues signaling different reward probabilities. In contrast to adults, adolescent rats did not flexibly adjust patterns of responding based on the expected likelihood of reward delivery but increased their rate of lever pressing for both weak and strong cues. These findings indicate that control over cue-motivated behavior is fundamentally dysregulated during adolescence, providing a model for studying neurobiological mechanisms of adolescent impulsivity.
Identifiants
pubmed: 32846387
pii: S1878-9293(20)30086-4
doi: 10.1016/j.dcn.2020.100838
pmc: PMC7451619
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100838Subventions
Organisme : NIA NIH HHS
ID : R01 AG045380
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106972
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
Neuron. 2011 Feb 24;69(4):680-94
pubmed: 21338879
PLoS One. 2012;7(10):e48227
pubmed: 23144742
Psychol Rev. 1967 May;74(3):151-82
pubmed: 5342881
Behav Brain Res. 2012 Apr 21;230(1):21-33
pubmed: 22326372
Psychol Rev. 1974 May;81(3):199-213
pubmed: 4424766
Behav Neurosci. 2018 Apr;132(2):75-87
pubmed: 29481101
J Neurosci. 2015 Oct 14;35(41):13975-88
pubmed: 26468198
J Exp Psychol Anim Behav Process. 1982 Jan;8(1):62-85
pubmed: 7057145
PLoS One. 2017 Jul 14;12(7):e0180907
pubmed: 28708901
Pharmacol Biochem Behav. 2009 Jun;92(4):566-73
pubmed: 19264093
Eur J Neurosci. 2004 Jan;19(1):181-9
pubmed: 14750976
Neuropsychopharmacology. 2006 Sep;31(9):2055-64
pubmed: 16482089
Behav Neurosci. 2003 Jun;117(3):566-87
pubmed: 12802885
Dev Psychobiol. 2010 Apr;52(3):216-24
pubmed: 20213754
Neuroimage. 2012 Aug 1;62(1):154-66
pubmed: 22548809
Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
pubmed: 10817843
PLoS One. 2013 Apr 30;8(4):e61355
pubmed: 23646106
Dev Cogn Neurosci. 2015 Dec;16:183-190
pubmed: 25575668
Eur J Neurosci. 2011 Jun;33(12):2274-87
pubmed: 21507084
Behav Brain Res. 2013 Nov 15;257:83-9
pubmed: 24050888
J Exp Psychol Learn Mem Cogn. 2009 May;35(3):709-30
pubmed: 19379045
Dev Psychobiol. 2020 Apr;62(3):368-379
pubmed: 31493315
J Neurosci. 2001 Oct 1;21(19):7831-40
pubmed: 11567074
Addict Biol. 2014 Nov;19(6):965-71
pubmed: 23639056
Brain Cogn. 2010 Feb;72(1):114-23
pubmed: 19762139
Learn Mem. 2018 Aug 16;25(9):399-409
pubmed: 30115761
Br J Psychol. 2009 Aug;100(Pt 3):603-17
pubmed: 19017432
Behav Brain Sci. 2018 Mar 8;:1-106
pubmed: 29514723
Trends Cogn Sci. 2005 May;9(5):242-9
pubmed: 15866151
Front Behav Neurosci. 2020 Jan 14;13:291
pubmed: 31992975
J Comp Physiol Psychol. 1971 Oct;77(1):131-5
pubmed: 5120676
Behav Neurosci. 2000 Jun;114(3):468-83
pubmed: 10883798
J Exp Psychol Anim Behav Process. 1983 Jul;9(3):225-47
pubmed: 6153052
J Youth Adolesc. 2015 Jan;44(1):1-17
pubmed: 24682958
Curr Top Behav Neurosci. 2016;27:259-89
pubmed: 26695169
J Exp Psychol Anim Behav Process. 2008 Apr;34(2):202-22
pubmed: 18426304
Neuropharmacology. 1998 Apr-May;37(4-5):461-9
pubmed: 9704987
Dev Psychobiol. 2017 Nov;59(7):840-847
pubmed: 28888030
Neurosci Biobehav Rev. 2010 Jul;34(8):1277-95
pubmed: 20385164
Neural Netw. 2006 Oct;19(8):1153-60
pubmed: 16938432
Cold Spring Harb Symp Quant Biol. 2018;83:37-43
pubmed: 30674651
Psychol Med. 2006 Mar;36(3):299-312
pubmed: 16472412
Behav Neurosci. 2011 Feb;125(1):93-105
pubmed: 21319891
Am J Psychiatry. 2003 Jun;160(6):1041-52
pubmed: 12777258
J Comp Neurol. 2010 Jul 15;518(14):2693-709
pubmed: 20506471
Ann N Y Acad Sci. 2008 Mar;1124:111-26
pubmed: 18400927
Front Integr Neurosci. 2010 May 28;4:
pubmed: 20725502
J Exp Anal Behav. 1970 Jan;13(1):67-73
pubmed: 5415041
Neurosci Biobehav Rev. 2016 Sep;68:1004-1005
pubmed: 27241200
Neuropharmacology. 1998 Apr-May;37(4-5):407-19
pubmed: 9704982
Multivariate Behav Res. 1995 Jan 1;30(1):1-21
pubmed: 26828342
Synapse. 2000 Aug;37(2):167-9
pubmed: 10881038
Neurosci Biobehav Rev. 2016 Dec;71:829-848
pubmed: 27693227
Pharmacol Biochem Behav. 2011 Apr;98(2):250-60
pubmed: 21238477
Front Behav Neurosci. 2010 Jul 13;4:
pubmed: 20700386
Dev Psychol. 2010 Jan;46(1):193-207
pubmed: 20053017
Front Behav Neurosci. 2020 Feb 04;14:3
pubmed: 32116587
Psychopharmacology (Berl). 2010 Feb;208(2):211-22
pubmed: 19953228
Addict Biol. 2019 Mar;24(2):193-205
pubmed: 29210144
Elife. 2019 May 20;8:
pubmed: 31107241
Front Behav Neurosci. 2015 May 07;9:115
pubmed: 25999830
Trends Ecol Evol. 2009 Mar;24(3):127-35
pubmed: 19185386
Psychol Rev. 1999 Jan;106(1):3-19
pubmed: 10197361
Behav Res Methods. 2007 Feb;39(1):101-17
pubmed: 17552476
Ann N Y Acad Sci. 2004 Jun;1021:51-8
pubmed: 15251873
J Neurosci. 2017 Nov 8;37(45):10855-10866
pubmed: 29118215
Behav Brain Res. 2003 Nov 30;146(1-2):145-57
pubmed: 14643467
J Stud Alcohol. 1992 Sep;53(5):447-57
pubmed: 1405637
Addict Biol. 2008 Sep;13(3-4):345-57
pubmed: 18782382
J Exp Psychol. 1948 Apr;38(2):173-7
pubmed: 18913666
Behav Neurosci. 2011 Aug;125(4):661-7
pubmed: 21534648
Nat Rev Neurosci. 2000 Oct;1(1):59-65
pubmed: 11252769
J Exp Psychol Anim Behav Process. 1975 Oct;1(4):355-63
pubmed: 1202141
Sci Rep. 2018 Feb 9;8(1):2766
pubmed: 29426846
Nat Commun. 2019 Dec 20;10(1):5826
pubmed: 31862876
J Exp Anal Behav. 1969 Jan;12(1):167-73
pubmed: 16811337
J Neurosci. 2012 Nov 14;32(46):16223-32
pubmed: 23152606
J Exp Psychol Anim Behav Process. 2004 Apr;30(2):104-17
pubmed: 15078120
Q J Exp Psychol B. 1981 Nov;33(Pt 4):257-69
pubmed: 7198814
J Neurosci. 2013 Mar 13;33(11):4913-22
pubmed: 23486962
Neuropsychopharmacology. 2014 Sep;39(10):2441-9
pubmed: 24804846
Dev Psychol. 2008 Nov;44(6):1764-78
pubmed: 18999337