Effect of unsaturated fatty acids on glycation product formation pathways (Ⅰ) the role of oleic acid.
Glycation pathways
Glycation products
Oleic acid
Orthogonal projection to latent structures discriminant analysis
Radicals
Journal
Food research international (Ottawa, Ont.)
ISSN: 1873-7145
Titre abrégé: Food Res Int
Pays: Canada
ID NLM: 9210143
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
10
04
2020
revised:
10
07
2020
accepted:
15
07
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
Research on advanced glycation end-products (AGEs) and their formation pathways in food processing has gradually increased because AGEs are associated with human health, especially with involvement of lipids. In this study, radicals and glycation products were detected via electron spin resonance (ESR) and ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) respectively. The correlation of important intermediates was used to explain the effect of oleic acid (OA) on the glycation products and pathways. The results indicated OA participation decreased the content of stable radicals and glycosyl compounds in Maillard Reaction (MR). The oxidation of OA produced active radicals, and electron transfer caused lysine to transform radical form. These radicals participated in the formation of fructosyllysine (FL) with glucose (Glc) via the MR. The participation of OA is acted as inhibiting the way of Glc autoxidation and promoting the glycation pathway from FL to 3-deoxyglucosone (3-DG) to fluorescent-AGEs. Orthogonal projection to latent structures discriminant analysis results indicated that 3-DG, D-glucosone and methylglyoxal are key products in discriminating the glycation reaction.
Identifiants
pubmed: 32846604
pii: S0963-9969(20)30585-8
doi: 10.1016/j.foodres.2020.109560
pii:
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Glycation End Products, Advanced
0
Oleic Acid
2UMI9U37CP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109560Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.