ITEM-THREE analysis of a monoclonal anti-malaria antibody reveals its assembled epitope on the

Amino Acid Sequence Animals Antibodies, Monoclonal / immunology Antigen-Antibody Complex / immunology Antigens, Protozoan / immunology Blotting, Western Electrophoresis, Polyacrylamide Gel / methods Epitope Mapping / methods Epitopes / immunology Malaria, Falciparum / immunology Merozoite Surface Protein 1 / immunology Spectrometry, Mass, Electrospray Ionization / methods
Plasmodium falciparum antigen assembled epitope conformational epitope epitope mapping malaria malaria screening. mass spectrometry mass spectrometry (MS) native MS pfMSP119 antigen pfMSP1_19 plasmodium protein-protein interaction

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
30 10 2020
Historique:
received: 12 06 2020
revised: 18 08 2020
pubmed: 28 8 2020
medline: 30 3 2021
entrez: 28 8 2020
Statut: ppublish

Résumé

Rapid diagnostic tests are first-line assays for diagnosing infectious diseases, such as malaria. To minimize false positive and false negative test results in population-screening assays, high-quality reagents and well-characterized antigens and antibodies are needed. An important property of antigen-antibody binding is recognition specificity, which best can be estimated by mapping an antibody's epitope on the respective antigen. We have cloned a malarial antigen-containing fusion protein, MBP-

Identifiants

DOI: 10.1074/jbc.RA120.014802 PMID: 32848020 PMC: PMC7606685
pubmed: 32848020
pii: S0021-9258(17)48906-X
doi: 10.1074/jbc.RA120.014802
pmc: PMC7606685
pii:
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antigen-Antibody Complex 0
Antigens, Protozoan 0
Epitopes 0
Merozoite Surface Protein 1 0

Banques de données

PDB
['1OB1']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14987-14997

Informations de copyright

© 2020 Opuni et al.

Déclaration de conflit d'intérêts

Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.

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Auteurs

Kwabena F M Opuni (KFM)

Proteome Center Rostock, University Medicine Rostock and University of Rostock, Rostock, Germany; Department of Pharmaceutical Chemistry, School of Pharmacy, College of Health, University of Ghana, Legon, Ghana.

Cornelia Koy (C)

Proteome Center Rostock, University Medicine Rostock and University of Rostock, Rostock, Germany.

Manuela Russ (M)

Proteome Center Rostock, University Medicine Rostock and University of Rostock, Rostock, Germany.

Maren Reepmeyer (M)

Proteome Center Rostock, University Medicine Rostock and University of Rostock, Rostock, Germany.

Bright D Danquah (BD)

Proteome Center Rostock, University Medicine Rostock and University of Rostock, Rostock, Germany.

Moritz Weresow (M)

I&L Biosystems GmbH, Königswinter, Germany.

Astrid Alef (A)

I&L Biosystems GmbH, Königswinter, Germany.

Peter Lorenz (P)

Institute for Immunology, University Medicine Rostock, Rostock, Germany.

Hans-Juergen Thiesen (HJ)

Institute for Immunology, University Medicine Rostock, Rostock, Germany.

Michael O Glocker (MO)

Proteome Center Rostock, University Medicine Rostock and University of Rostock, Rostock, Germany. Electronic address: michael.glocker@med.uni-rostock.de.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › ITEM-THREE analysis of a monoclonal...
questionsmedicales.fr › Eucaryotes › Animaux › ITEM-THREE analysis of a monoclonal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › ITEM-THREE analysis of a monoclonal...
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questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Électrophorèse › Électrophorèse sur gel de polyacrylamide › ITEM-THREE analysis of a monoclonal...
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