Activation of Toll-Like Receptors Differentially Modulates Inflammation in the Human Reproductive Tract: Preliminary Findings.
Cells, Cultured
Cytokines
/ metabolism
Female
Humans
Imidazoles
/ pharmacology
Immunity, Mucosal
/ drug effects
Inflammation Mediators
/ metabolism
Leukocytes, Mononuclear
/ drug effects
Lipopolysaccharides
/ pharmacology
Lymphocytes
/ drug effects
Oligodeoxyribonucleotides
/ pharmacology
Phenotype
Poly I-C
/ pharmacology
Signal Transduction
Toll-Like Receptors
/ agonists
Uterus
/ drug effects
Vagina
/ drug effects
Toll-like receptors (TLR)
cytokines and chemokines
female reproductive tract (FRT)
immune cells
inflammation
mucosa
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
04
2020
accepted:
22
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
13
4
2021
Statut:
epublish
Résumé
The female reproductive tract (FRT) is the main site of entry of sexually transmitted infections (STIs). Toll-like receptors (TLRs) that recognize pathogenic motifs are widely expressed in the FRT. TLR stimulation induces immune activation and local production of inflammatory mediators. In the FRT, this response should also be compatible with reproductive functions and symbiosis with host microbiota. With a view to develop efficient mucosal vaccines to prevent STI acquisition, the role of TLR ligands in the FRT needs to be explored. We have therefore investigated the cytokine profiles of the different compartments of the FRT (vagina, endocervix, ectocervix, and uterus) before and after stimulation of mononuclear cells from human tissue specimens. The comparison with PBMCs allowed us to highlight the FRT specificities. We first characterized the main immune cell populations in each compartment and observed that their distribution was different through the compartments. The CD45
Identifiants
pubmed: 32849571
doi: 10.3389/fimmu.2020.01655
pmc: PMC7417306
doi:
Substances chimiques
CPG-oligonucleotide
0
Cytokines
0
Imidazoles
0
Inflammation Mediators
0
Lipopolysaccharides
0
Oligodeoxyribonucleotides
0
Toll-Like Receptors
0
Poly I-C
O84C90HH2L
resiquimod
V3DMU7PVXF
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1655Informations de copyright
Copyright © 2020 Benjelloun, Quillay, Cannou, Marlin, Madec, Fernandez, Chrétien, Le Grand, Barré-Sinoussi, Nugeyre and Menu.
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