O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
05
2020
revised:
21
06
2020
accepted:
27
07
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
15
5
2021
Statut:
epublish
Résumé
Since both O-GlcNAcylation and autophagy sense intracellular nutrient level, the alteration of those two pathways plays substantial roles in the progression of heart failure. Hence, determining the relationship between O-GlcNAcylation and autophagy is imperative to understand, prevent, and treat heart failure. However, the mechanism on how O-GlcNAcylation regulates autophagy in the heart is poorly investigated. In this study, we demonstrated that O-GlcNAcylation is required for autophagy in cardiomyocytes by utilizing an O-linked
Identifiants
pubmed: 32850000
doi: 10.1155/2020/5602396
pmc: PMC7439163
doi:
Substances chimiques
N-Acetylglucosaminyltransferases
EC 2.4.1.-
UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase
EC 2.4.1.-
Autophagy-Related Protein-1 Homolog
EC 2.7.11.1
Ulk1 protein, mouse
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5602396Informations de copyright
Copyright © 2020 Houzhi Yu et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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