Antibiotic prophylaxis for prevention of wound infections after soft tissue sarcoma resection: A retrospective cohort study.
Adult
Aged
Anti-Bacterial Agents
/ therapeutic use
Antibiotic Prophylaxis
/ methods
Female
Follow-Up Studies
Humans
Male
Middle Aged
Postoperative Complications
/ etiology
Prognosis
Retrospective Studies
Risk Factors
Sarcoma
/ drug therapy
Surgical Procedures, Operative
/ adverse effects
Surgical Wound Infection
/ etiology
antibiotic prophylaxis
sarcoma
soft tissue sarcoma
wound infection
Journal
Journal of surgical oncology
ISSN: 1096-9098
Titre abrégé: J Surg Oncol
Pays: United States
ID NLM: 0222643
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
04
07
2020
revised:
27
07
2020
accepted:
14
08
2020
pubmed:
28
8
2020
medline:
5
1
2021
entrez:
28
8
2020
Statut:
ppublish
Résumé
The use of antibiotic prophylaxis for soft tissue sarcoma resection varies widely while little evidence on this topic exists. The aim of this study was to determine the impact of antibiotic prophylaxis on the occurrence of wound infections. A single institutional retrospective cohort study was performed on patients who underwent truncal or extremity soft tissue sarcoma resection. The use of antibiotic prophylaxis was assessed and univariate and multivariate analysis of predictors of wound infections was performed. Nine hundred and fifty-eight patients could be included. Thirty-two percent of patients had no antibiotic prophylaxis, 44% of patients received single-shot prophylaxis, and 24% of patients received single-shot plus continued antibiotic treatment. Wound infections occurred in 140 patients (15%). Independent risk factors for wound infections upon multivariate analysis were obesity, high American Society of Anesthesiologists (ASA) status, high tumor size and grade, operation time over 120 minutes, and other complications. Antibiotic prophylaxis could not be identified as a protective factor in univariate or multivariate analysis. A favorable effect of antibiotic prophylaxis on the occurrence of wound infections could not be observed. Although more studies on this subject are needed, our data do not support the general use of antibiotic prophylaxis for soft tissue sarcoma resection.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
The use of antibiotic prophylaxis for soft tissue sarcoma resection varies widely while little evidence on this topic exists. The aim of this study was to determine the impact of antibiotic prophylaxis on the occurrence of wound infections.
METHODS
METHODS
A single institutional retrospective cohort study was performed on patients who underwent truncal or extremity soft tissue sarcoma resection. The use of antibiotic prophylaxis was assessed and univariate and multivariate analysis of predictors of wound infections was performed.
RESULTS
RESULTS
Nine hundred and fifty-eight patients could be included. Thirty-two percent of patients had no antibiotic prophylaxis, 44% of patients received single-shot prophylaxis, and 24% of patients received single-shot plus continued antibiotic treatment. Wound infections occurred in 140 patients (15%). Independent risk factors for wound infections upon multivariate analysis were obesity, high American Society of Anesthesiologists (ASA) status, high tumor size and grade, operation time over 120 minutes, and other complications. Antibiotic prophylaxis could not be identified as a protective factor in univariate or multivariate analysis.
CONCLUSIONS
CONCLUSIONS
A favorable effect of antibiotic prophylaxis on the occurrence of wound infections could not be observed. Although more studies on this subject are needed, our data do not support the general use of antibiotic prophylaxis for soft tissue sarcoma resection.
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1685-1692Informations de copyright
© 2020 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.
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