Ethyl Alcohol Versus Botulinum Toxin A: A Comparative Study of the Visual and Histopathological Outcomes in the Rabbit Anterior Auricular Muscle Model.
Animals
Botulinum Toxins, Type A
/ administration & dosage
Drug Evaluation, Preclinical
Ear, External
/ diagnostic imaging
Ethanol
/ administration & dosage
Female
Injections, Intramuscular
Models, Animal
Muscle Contraction
/ drug effects
Muscle, Skeletal
/ drug effects
Neuromuscular Agents
/ administration & dosage
Neuromuscular Junction
/ drug effects
Photography
Rabbits
Time Factors
Journal
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
ISSN: 1524-4725
Titre abrégé: Dermatol Surg
Pays: United States
ID NLM: 9504371
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
28
8
2020
medline:
20
1
2021
entrez:
28
8
2020
Statut:
ppublish
Résumé
Botulinum toxin has long been known for its paralytic effects at the neuromuscular junction. Although it has been widely used for vascular and nervous tissues, there has been no study of the aesthetic effects of the application of ethanol to muscle tissues to date. The authors aimed to demonstrate the effects of the application of ethanol to muscle tissues after an intramuscular injection and to compare the effects of botulinum toxin A (BTA) and ethanol. A total of 28 rabbits were divided into 4 groups (n = 7 each). Botulinum toxin A (5 units) and different concentrations of ethanol (5 cc) were injected into the left and right anterior auricular muscles of all rabbits, respectively. Ear ptosis was assessed, and histopathological examination was performed after all rabbits were euthanized in the eighth week. Muscle function was affected earlier in ethanol-treated ears than in botulinum-treated ears; however, the ptotic effect lasted for a significantly shorter duration in ethanol-injected ears than in BTA-applied ears. Ethanol can block muscle function reversibly and can serve as an alternative to BTA, particularly when rapid results are desirable.
Sections du résumé
BACKGROUND
Botulinum toxin has long been known for its paralytic effects at the neuromuscular junction. Although it has been widely used for vascular and nervous tissues, there has been no study of the aesthetic effects of the application of ethanol to muscle tissues to date.
OBJECTIVE
The authors aimed to demonstrate the effects of the application of ethanol to muscle tissues after an intramuscular injection and to compare the effects of botulinum toxin A (BTA) and ethanol.
METHODS AND MATERIALS
A total of 28 rabbits were divided into 4 groups (n = 7 each). Botulinum toxin A (5 units) and different concentrations of ethanol (5 cc) were injected into the left and right anterior auricular muscles of all rabbits, respectively. Ear ptosis was assessed, and histopathological examination was performed after all rabbits were euthanized in the eighth week.
RESULTS
Muscle function was affected earlier in ethanol-treated ears than in botulinum-treated ears; however, the ptotic effect lasted for a significantly shorter duration in ethanol-injected ears than in BTA-applied ears.
CONCLUSION
Ethanol can block muscle function reversibly and can serve as an alternative to BTA, particularly when rapid results are desirable.
Identifiants
pubmed: 32852430
doi: 10.1097/DSS.0000000000002600
pii: 00042728-202012000-00041
doi:
Substances chimiques
Neuromuscular Agents
0
Ethanol
3K9958V90M
Botulinum Toxins, Type A
EC 3.4.24.69
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1661-1666Commentaires et corrections
Type : CommentIn
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