Sickle Cell-Related Complications in Patients Undergoing Cardiopulmonary Bypass.
Adolescent
Adult
Anemia, Sickle Cell
/ complications
Cardiac Surgical Procedures
/ adverse effects
Cardiopulmonary Bypass
/ adverse effects
Child
Child, Preschool
Female
Heart Defects, Congenital
/ complications
Humans
Hypothermia, Induced
/ adverse effects
Infant
Infant, Newborn
Male
Postoperative Complications
Retrospective Studies
Young Adult
cardiopulmonary bypass (CPB)
congenital heart disease (CHD)
pediatric
sickle cell trait disease
Journal
World journal for pediatric & congenital heart surgery
ISSN: 2150-136X
Titre abrégé: World J Pediatr Congenit Heart Surg
Pays: United States
ID NLM: 101518415
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
5
1
2021
Statut:
ppublish
Résumé
We aimed to describe our experience with patients with sickle cell trait (SCT) and undergoing surgery on cardiopulmonary bypass (CPB). Data on all patients with SCT or sickle-α thalassemia who underwent surgery on CPB were collected (1996-2017). Overall, 46 patients were included, 37 (80%) had SCT and 9 (20%) had sickle-α thalassemia. A total of 4 (9%) developed a potential sickle cell-related complication. Patients with sickle cell-related complications were significantly older (median 14 years vs 14 months, In this retrospective, single-center study, it has been shown that cardiac surgery requiring CPB in patients with SCT and sickle-α thalassemia had a low risk for sickle cell-associated complications. In this cohort of patients, older age, longer CPB times, lower median temperature, and the utilization of deep hypothermic circulatory arrest appear to play an important role in the development of complications.
Sections du résumé
BACKGROUND
We aimed to describe our experience with patients with sickle cell trait (SCT) and undergoing surgery on cardiopulmonary bypass (CPB).
METHODS
Data on all patients with SCT or sickle-α thalassemia who underwent surgery on CPB were collected (1996-2017).
RESULTS
Overall, 46 patients were included, 37 (80%) had SCT and 9 (20%) had sickle-α thalassemia. A total of 4 (9%) developed a potential sickle cell-related complication. Patients with sickle cell-related complications were significantly older (median 14 years vs 14 months,
CONCLUSIONS
In this retrospective, single-center study, it has been shown that cardiac surgery requiring CPB in patients with SCT and sickle-α thalassemia had a low risk for sickle cell-associated complications. In this cohort of patients, older age, longer CPB times, lower median temperature, and the utilization of deep hypothermic circulatory arrest appear to play an important role in the development of complications.
Identifiants
pubmed: 32853076
doi: 10.1177/2150135120926991
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM