Determination by ICP-MS and multivariate data analysis of elemental urine excretion profile during the EDTA chelation therapy: A case study.

Chelation Therapy Data Analysis Edetic Acid / chemistry Humans Mass Spectrometry / methods
Chelation therapy Elemental profile ICP-MS Metal intoxication Multivariate data analysis Urine

Journal

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 30 07 2019
revised: 04 06 2020
accepted: 30 06 2020
pubmed: 28 8 2020
medline: 28 9 2021
entrez: 28 8 2020
Statut: ppublish

Résumé

Based on the medical history and laboratory analytical tests, a patient presenting symptoms compatible with Chronic Fatigue Syndrome was suspected of metal intoxication; therefore, a chelating therapy was attempted. In parallel, the profile of elemental excretion in urine was determined. Chelation therapy by CaNa Most of the toxic elements showed a peak of excretion in 12-24 h after EDTA administration, which returned to basal level by 24-36 h after the treatment. Yet, the excretion of some trace elements persisted in the urine collected 26 h after the treatment. The analysis of excreted metals following the CaNa

Sections du résumé

BACKGROUND BACKGROUND
Based on the medical history and laboratory analytical tests, a patient presenting symptoms compatible with Chronic Fatigue Syndrome was suspected of metal intoxication; therefore, a chelating therapy was attempted. In parallel, the profile of elemental excretion in urine was determined.
METHODS METHODS
Chelation therapy by CaNa
RESULTS RESULTS
Most of the toxic elements showed a peak of excretion in 12-24 h after EDTA administration, which returned to basal level by 24-36 h after the treatment. Yet, the excretion of some trace elements persisted in the urine collected 26 h after the treatment.
CONCLUSIONS CONCLUSIONS
The analysis of excreted metals following the CaNa

Identifiants

DOI: 10.1016/j.jtemb.2020.126608 PMID: 32853885
pubmed: 32853885
pii: S0946-672X(20)30173-5
doi: 10.1016/j.jtemb.2020.126608
pii:
doi:

Substances chimiques

Edetic Acid 9G34HU7RV0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

126608

Informations de copyright

Copyright © 2020 Elsevier GmbH. All rights reserved.

Auteurs

Elisa Robotti (E)

Department of Sciences and Technological Innovation, University of Piemonte Orientale, Viale Michel 11, 15121, Alessandria, Italy. Electronic address: elisa.robotti@uniupo.it.

Fabio Quasso (F)

Department of Sciences and Technological Innovation, University of Piemonte Orientale, Viale Michel 11, 15121, Alessandria, Italy. Electronic address: fq004@libero.it.

Marcello Manfredi (M)

Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy; Isalit srl, c/o IPAZIA, Corso Trieste 15/A, 28100 Novara, Italy. Electronic address: marcello.manfredi@uniupo.it.

Fabio Gosetti (F)

Department of Earth and Environmental Sciences, University of Milano-Bicocca, Piazza Della Scienza 1, 20126, Milano, Italy. Electronic address: fabio.gosetti@unimib.it.

Eleonora Mazzucco (E)

Isalit srl, c/o IPAZIA, Corso Trieste 15/A, 28100 Novara, Italy. Electronic address: eleonora.mazzucco@uniupo.it.

Ciro Isidoro (C)

Department of Health Sciences, University of Piemonte Orientale, Via P. Solaroli 17, 28100, Novara, Italy. Electronic address: ciro.isidoro@med.uniupo.it.

Emilio Marengo (E)

Department of Sciences and Technological Innovation, University of Piemonte Orientale, Viale Michel 11, 15121, Alessandria, Italy. Electronic address: emilio.marengo@uniupo.it.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitement chélateur › Determination by ICP-MS and multivariate data...
questionsmedicales.fr › Disciplines des sciences naturelles › Mathématiques › Analyse de données › Determination by ICP-MS and multivariate data...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Acide édétique › Determination by ICP-MS and multivariate data...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Determination by ICP-MS and multivariate data...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Determination by ICP-MS and multivariate data...