Optimisation and Validation of a Nutritional Intervention to Enhance Sleep Quality and Quantity.
nutrition
polysomnography
sleep onset latency
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
25 Aug 2020
25 Aug 2020
Historique:
received:
07
07
2020
revised:
19
08
2020
accepted:
20
08
2020
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
23
3
2021
Statut:
epublish
Résumé
Disturbed sleep may negatively influence physical health, cognitive performance, metabolism, and general wellbeing. Nutritional interventions represent a potential non-pharmacological means to increase sleep quality and quantity. (1) Identify an optimal suite of nutritional ingredients and (2) validate the effects of this suite utilising polysomnography, and cognitive and balance tests. The optimal and least optimal combinations of six ingredients were identified utilising 55 male participants and a Box-Behnken predictive model. To validate the model, 18 healthy, male, normal sleepers underwent three trials in a randomised, counterbalanced design: (1) optimal drink, (2) least optimal drink, or (3) placebo were provided before bed in a double-blinded manner. Polysomnography was utilised to measure sleep architecture. Cognitive performance, postural sway, and subjective sleep quality, were assessed 30 min after waking. The optimal drink resulted in a significantly shorter sleep onset latency (9.9 ± 12.3 min) when compared to both the least optimal drink (26.1 ± 37.4 min) and the placebo drink (19.6 ± 32.0 min). No other measures of sleep, cognitive performance, postural sway, and subjective sleep quality were different between trials. A combination of ingredients, optimised to enhance sleep, significantly reduced sleep onset latency. No detrimental effects on sleep architecture, subjective sleep quality or next day performance were observed.
Sections du résumé
BACKGROUND
BACKGROUND
Disturbed sleep may negatively influence physical health, cognitive performance, metabolism, and general wellbeing. Nutritional interventions represent a potential non-pharmacological means to increase sleep quality and quantity.
OBJECTIVE
OBJECTIVE
(1) Identify an optimal suite of nutritional ingredients and (2) validate the effects of this suite utilising polysomnography, and cognitive and balance tests.
METHODS
METHODS
The optimal and least optimal combinations of six ingredients were identified utilising 55 male participants and a Box-Behnken predictive model. To validate the model, 18 healthy, male, normal sleepers underwent three trials in a randomised, counterbalanced design: (1) optimal drink, (2) least optimal drink, or (3) placebo were provided before bed in a double-blinded manner. Polysomnography was utilised to measure sleep architecture. Cognitive performance, postural sway, and subjective sleep quality, were assessed 30 min after waking.
RESULTS
RESULTS
The optimal drink resulted in a significantly shorter sleep onset latency (9.9 ± 12.3 min) when compared to both the least optimal drink (26.1 ± 37.4 min) and the placebo drink (19.6 ± 32.0 min). No other measures of sleep, cognitive performance, postural sway, and subjective sleep quality were different between trials.
CONCLUSION
CONCLUSIONS
A combination of ingredients, optimised to enhance sleep, significantly reduced sleep onset latency. No detrimental effects on sleep architecture, subjective sleep quality or next day performance were observed.
Identifiants
pubmed: 32854375
pii: nu12092579
doi: 10.3390/nu12092579
pmc: PMC7551573
pii:
doi:
Substances chimiques
Glutamates
0
Adenosine Monophosphate
415SHH325A
theanine
8021PR16QO
Tryptophan
8DUH1N11BX
Lactalbumin
9013-90-5
Types de publication
Journal Article
Randomized Controlled Trial
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : PepsiCo
ID : PEP-1420
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