Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.
Animals
Antipsychotic Agents
/ chemical synthesis
Behavior, Animal
/ drug effects
Disease Models, Animal
Hep G2 Cells
Humans
Mice
Molecular Docking Simulation
Phosphoric Diester Hydrolases
/ chemistry
Receptor, Serotonin, 5-HT1A
/ chemistry
Receptors, Serotonin
/ chemistry
Schizophrenia
/ drug therapy
Structure-Activity Relationship
antipsychotic activity
benzimidazole derivatives
phosphodiesterase 10A
schizophrenia
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Aug 2020
25 Aug 2020
Historique:
received:
04
08
2020
revised:
22
08
2020
accepted:
23
08
2020
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
12
3
2021
Statut:
epublish
Résumé
In this study, a series of compounds derived from 4-methoxy-1
Identifiants
pubmed: 32854402
pii: molecules25173868
doi: 10.3390/molecules25173868
pmc: PMC7504677
pii:
doi:
Substances chimiques
Antipsychotic Agents
0
Htr1a protein, mouse
0
Receptors, Serotonin
0
serotonin 7 receptor
0
Receptor, Serotonin, 5-HT1A
112692-38-3
PDE10A protein, human
EC 3.1.4.-
Pde10a protein, mouse
EC 3.1.4.-
Phosphoric Diester Hydrolases
EC 3.1.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : DEC-2012/07/B/NZ7/01173
Organisme : Narodowe Centrum Nauki
ID : 2016/21/D/NZ7/01573
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : N42/DBS/000104
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : N42/DBS/0001784
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : N42/DBS/000020
Références
Curr Pharm Des. 2010;16(5):488-501
pubmed: 19909227
Psychopharmacology (Berl). 2009 May;203(4):723-35
pubmed: 19066855
J Med Chem. 2012 Sep 13;55(17):7299-331
pubmed: 22834877
Curr Opin Pharmacol. 2011 Feb;11(1):59-67
pubmed: 21420906
Chemistry. 2015 Jul 13;21(29):10322-5
pubmed: 26074213
Food Chem Toxicol. 2014 Mar;65:335-42
pubmed: 24412706
J Med Chem. 2019 Jan 24;62(2):420-444
pubmed: 30035545
Bioorg Med Chem Lett. 2011 Jun 15;21(12):3738-42
pubmed: 21602043
Bioorg Med Chem. 2002 Sep;10(9):3067-73
pubmed: 12110331
Bioorg Med Chem. 2014 Jan 1;22(1):550-8
pubmed: 24268539
Molecules. 2015 Sep 14;20(9):16620-42
pubmed: 26389864
J Clin Psychiatry. 2001 Nov;62(11):841-2
pubmed: 11775041
Bioorg Med Chem. 2014 Jul 1;22(13):3515-26
pubmed: 24837154
Molecules. 2018 Feb 07;23(2):
pubmed: 29414887
Bioorg Med Chem Lett. 2007 Jan 15;17(2):476-81
pubmed: 17092715
Int J Mol Sci. 2013 Mar 11;14(3):5608-32
pubmed: 23478436
Curr Pharm Des. 2015;21(26):3725-31
pubmed: 26044980
J Med Chem. 2009 Apr 23;52(8):2384-92
pubmed: 19326916
J Clin Psychopharmacol. 1995 Feb;15(1 Suppl 1):4S-10S
pubmed: 7730499
Acta Pol Pharm. 2016 Nov;73(6):1545-1554
pubmed: 29634109
Int J Mol Sci. 2018 Oct 10;19(10):
pubmed: 30309037
Iran J Basic Med Sci. 2017 Jan;20(1):59-66
pubmed: 28133526
J Pharmacol Exp Ther. 2008 May;325(2):681-90
pubmed: 18287214
Bioorg Med Chem Lett. 2012 Sep 15;22(18):5876-84
pubmed: 22902656
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26
pubmed: 11259830
Biomed Pharmacother. 1997;51(10):464-8
pubmed: 9863507
Biomed Pharmacother. 1995;49(5):251-8
pubmed: 7579004
Expert Opin Investig Drugs. 2005 May;14(5):601-18
pubmed: 15926867
Pharmacol Res Perspect. 2018 Feb;6(1):
pubmed: 29417763
J Enzyme Inhib Med Chem. 2016;31(sup3):10-24
pubmed: 27353547
Psychiatry Clin Neurosci. 2015 May;69(5):243-58
pubmed: 25296946
Neuroreport. 2009 Feb 18;20(3):325-30
pubmed: 19190523
Bioorg Med Chem. 2017 Feb 1;25(3):1250-1259
pubmed: 28063784
Biomed Pharmacother. 1993;47(10):463-4
pubmed: 8061248
Curr Med Chem. 2018;25(29):3455-3481
pubmed: 29521210
Bioorg Med Chem. 2012 Feb 15;20(4):1545-56
pubmed: 22277589
J Comb Chem. 2010 Jan-Feb;12(1):151-60
pubmed: 19928911
J Med Chem. 2011 Jan 13;54(1):342-53
pubmed: 21155570