Circadian clock mechanism driving mammalian photoperiodism.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
27 08 2020
27 08 2020
Historique:
received:
16
01
2020
accepted:
27
07
2020
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
25
9
2020
Statut:
epublish
Résumé
The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies support the universality of this so-called coincidence timer, but we lack understanding of the mechanisms involved. Here we show in mammals that long photoperiods induce the circadian transcription factor BMAL2, in the pars tuberalis of the pituitary, and triggers summer biology through the eyes absent/thyrotrophin (EYA3/TSH) pathway. Conversely, long-duration melatonin signals on short photoperiods induce circadian repressors including DEC1, suppressing BMAL2 and the EYA3/TSH pathway, triggering winter biology. These actions are associated with progressive genome-wide changes in chromatin state, elaborating the effect of the circadian coincidence timer. Hence, circadian clock-pituitary epigenetic pathway interactions form the basis of the mammalian coincidence timer mechanism. Our results constitute a blueprint for circadian-based seasonal timekeeping in vertebrates.
Identifiants
pubmed: 32855407
doi: 10.1038/s41467-020-18061-z
pii: 10.1038/s41467-020-18061-z
pmc: PMC7453030
doi:
Substances chimiques
ARNTL Transcription Factors
0
DNA-Binding Proteins
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4291Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBP013759/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107851/Z/15/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015584/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015347/1
Pays : United Kingdom
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