Challenges in diagnosing necrotizing enterocolitis.
Biomarkers
Disease Progression
Enterocolitis, Necrotizing
/ classification
Feces
Gastrointestinal Microbiome
Humans
Infant
Infant, Newborn
Infant, Newborn, Diseases
/ classification
Infant, Premature
Infant, Premature, Diseases
/ classification
Intestines
/ diagnostic imaging
Machine Learning
Neonatology
/ standards
Reproducibility of Results
Risk
Sensitivity and Specificity
Treatment Outcome
Ultrasonography
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
24
8
2021
Statut:
ppublish
Résumé
One of the many challenges with necrotizing enterocolitis (NEC) remains our inability to make an accurate diagnosis of NEC. The lack of a unifying cause and multiple variations in presentations lead to great uncertainty with NEC. Separating out the needs of the researcher wanting to define NEC from the clinician and patient family's perspectives who want an accurate diagnosis for NEC is important. The need to augment and/or replace the outdated modified Bell staging criteria is crucial to improving NEC management. Emerging literature suggests that genetic susceptibility and stool microbiota signatures may help identify preterm infants at increased risk of the disease. Ongoing studies using single or multi-omic approaches may help to characterize biomarkers that will aid in the prediction or early diagnosis of NEC, as well as differentiate other causes of severe bowel injury. Bowel ultrasound shows promise in improving our diagnostic accuracy for NEC but has been slow in adoption. Patient family perspectives are key in accelerating our efforts to integrate newer diagnostic methods into practice.
Identifiants
pubmed: 32855507
doi: 10.1038/s41390-020-1090-4
pii: 10.1038/s41390-020-1090-4
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-20Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK117296
Pays : United States
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