The role of six biomarkers in diagnosis of hemophilic arthropathy: review of the literature.
biomarkers
hemarthrosis
hemophilia
hemophilic arthropathy
synovitis
Journal
Journal of biological regulators and homeostatic agents
ISSN: 0393-974X
Titre abrégé: J Biol Regul Homeost Agents
Pays: Italy
ID NLM: 8809253
Informations de publication
Date de publication:
Historique:
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
6
11
2020
Statut:
ppublish
Résumé
The aim of our narrative review of the literature is to identify the role of six important biomarkers: synovial fluid thrombomodulin, fibroblast-like synoviocytes, synovial tissue growth factor , vascular endothelial growth factor in synovium and peripheral blood, urinary C-terminal telopeptide of type II collagen, and synovial fluid tumor necrosis factor alpha. These urinary, serum and synovial biomarkers illustrated should be evaluated in patients with hemophilic arthropathy for early diagnosis of hemophilic arthropathy, because they have important implications in the development of arthrofibrosis, altered inflammatory response and bleeding. Moreover, better knowledge of their biological activity is important to identify possible new biological treatment options.
Substances chimiques
Biomarkers
0
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-13. ADVANCES IN MUSCULOSKELETAL DISEASES AND INFECTIONS - SOTIMI 2019Informations de copyright
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