A chemical covalent tactic for bio-thiol sensing and protein labeling agent design.

Drug Design Fluorescent Dyes / chemical synthesis Hep G2 Cells Humans Molecular Structure Safrole / analogs & derivatives Sulfhydryl Compounds / analysis

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
29 Sep 2020
Historique:
pubmed: 29 8 2020
medline: 27 4 2021
entrez: 29 8 2020
Statut: ppublish

Résumé

Discovering novel chemical reactions is important for bioanalysis. Herein, we report a tactic for bio-thiol sensing and protein labeling agent design by the installation of a sulfoxide group onto the skeleton of various fluorophores, and powerfully validate its abilities, which may shed light on the development of specific protein tags to give insight into their biological functions.

Identifiants

DOI: 10.1039/d0cc04169f PMID: 32857068
pubmed: 32857068
doi: 10.1039/d0cc04169f
doi:

Substances chimiques

Fluorescent Dyes 0
Sulfhydryl Compounds 0
Safrole RSB34337V9
sulfoxide WOR3CS513R

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11485-11488

Auteurs

Liangwei Zhang (L)

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn lxchen@yic.ac.cn.

Jie Kang (J)

Shudi Liu (S)

Xia Zhang (X)

Jinyu Sun (J)

Yuesong Hu (Y)

Yang Yang (Y)

Lingxin Chen (L)

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › A chemical covalent tactic for bio-thiol...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › A chemical covalent tactic for bio-thiol...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › A chemical covalent tactic for bio-thiol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A chemical covalent tactic for bio-thiol...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › A chemical covalent tactic for bio-thiol...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzodioxoles › Safrole › A chemical covalent tactic for bio-thiol...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › A chemical covalent tactic for bio-thiol...