Clinical importance of "occult-bacterial translocation" in patients undergoing highly invasive gastrointestinal surgery: A review.
Anti-Bacterial Agents
Bacteria
/ isolation & purification
Bacterial Translocation
Blood
/ microbiology
Esophageal Neoplasms
/ surgery
Esophagectomy
/ adverse effects
Humans
Incidence
Infections
/ epidemiology
Lymph Nodes
/ microbiology
Mesentery
Postoperative Complications
/ epidemiology
Stress, Physiological
Bacteremia
Bacterial translocation
Gastrointestinal surgery
Mesenteric lymph node
Journal
Surgery today
ISSN: 1436-2813
Titre abrégé: Surg Today
Pays: Japan
ID NLM: 9204360
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
08
05
2020
accepted:
25
07
2020
pubmed:
29
8
2020
medline:
16
9
2021
entrez:
29
8
2020
Statut:
ppublish
Résumé
In the clinical setting, mild bacteremia cannot be detected by conventional culture methods, only by a highly sensitive bacterial detection system. One of the major causes of mild bacteremia is bacterial translocation (BT) induced by a dysregulated intestinal microenvironment and increased intestinal epithelial permeability. This condition is called "occult-bacterial translocation (O-BT)"; however, the concept of O-BT is not yet fully recognized. In our previous studies, done using a highly sensitive bacterial detection system such as bacterium-specific ribosomal RNA-targeted reverse transcriptase quantitative polymerase chain reaction (RT-qPCR), O-BT was commonly observed in patients who underwent highly invasive surgery. We collected blood and mesenteric lymph node (MLN) samples from patients undergoing esophagectomy for esophageal cancer, before and after they were subjected to surgical stress. The detection rate of bacteria in these samples increased from approximately 20% before surgical stress to more than 50% after surgical stress. Moreover, positivity for bacteria in the blood or MLN samples was associated with the incidence of postoperative infectious complications (POICs). Using the RT-qPCR system, it is possible to detect the specific bacteria that cause O-BT immediately after surgery. This may allow us to select the exact antibiotic that targets possible pathogenic bacteria of POICs.
Identifiants
pubmed: 32857253
doi: 10.1007/s00595-020-02126-z
pii: 10.1007/s00595-020-02126-z
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-492Références
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