Self-reported disability in relation to mortality in rural Malawi: a longitudinal study of over 16 000 adults.


Journal

BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874

Informations de publication

Date de publication:
27 08 2020
Historique:
entrez: 30 8 2020
pubmed: 30 8 2020
medline: 15 5 2021
Statut: epublish

Résumé

We investigated whether self-reported disability was associated with mortality in adults in rural Malawi. Karonga Health and Demographic Surveillance Site (HDSS), Northern Malawi. All adults aged 18 and over residing in the HDSS were eligible to participate. During annual censuses in 2014 and 2015, participants were asked if they experienced difficulty in any of six functional domains and were classified as having disabilities if they reported 'a lot of difficulty' or 'can't do at all' in any domain. Mortality data were collected until 31 December 2017. 16 748 participants (10 153 women and 6595 men) were followed up for a median of 29 months. We used Poisson regression to examine the relationship between disability and all-cause mortality adjusting for confounders. We assessed whether this relationship altered in the context of obesity, hypertension, diabetes or HIV. We also evaluated whether mortality from non-communicable diseases (NCD) was higher among people who had reported disability, as determined by verbal autopsy. At baseline, 7.6% reported a disability and the overall adult mortality rate was 9.1/1000 person-years. Adults reporting disability had an all-cause mortality rate 2.70 times higher than those without, and mortality rate from NCDs 2.33 times higher than those without. Self-reported disability predicts mortality at all adult ages in rural Malawi. Interventions to improve access to healthcare and other services are needed.

Identifiants

pubmed: 32859660
pii: bmjopen-2019-034802
doi: 10.1136/bmjopen-2019-034802
pmc: PMC7454196
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e034802

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098610
Pays : United Kingdom

Informations de copyright

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Josephine E Prynn (JE)

Institute of Cardiovascular Science, University College London, London, UK josephineprynn@gmail.com.
Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.

Albert Dube (A)

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.

Joseph Mkandawire (J)

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.

Olivier Koole (O)

Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

Steffen Geis (S)

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.
Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

Elenaus Mwaiyeghele (E)

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.

Oddie Mwiba (O)

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.

Alison J Price (AJ)

Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

Lackson Kachiwanda (L)

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.

Moffat Nyirenda (M)

Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
NCD Phenotype Programme, MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Wakiso, Uganda.

Hannah Kuper (H)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.

Amelia C Crampin (AC)

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.
Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

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