Secreted Factors from Adipose Tissue Reprogram Tumor Lipid Metabolism and Induce Motility by Modulating PPARα/ANGPTL4 and FAK.
Adipose Tissue
/ cytology
Angiopoietin-Like Protein 4
/ genetics
Animals
Breast Neoplasms
/ genetics
Cell Line, Tumor
Coculture Techniques
Diet, High-Fat
/ adverse effects
Disease Models, Animal
Female
Focal Adhesion Kinase 1
/ genetics
Gene Expression Regulation
Gene Expression Regulation, Neoplastic
Humans
Lipid Metabolism
Mice
Obesity
/ chemically induced
PPAR alpha
/ genetics
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
19
12
2019
revised:
16
07
2020
accepted:
24
08
2020
pubmed:
30
8
2020
medline:
28
9
2021
entrez:
30
8
2020
Statut:
ppublish
Résumé
Recent studies indicate that adipose tissue in obesity promotes breast cancer progression by secreting protumorigenic chemokines, growth factors, and fatty acids. However, the detailed mechanisms by which hypertrophic adipose tissue influences breast cancer cells are still not well understood. Here we show that co-culture with adipose tissue from high-fat diet induced obese C57BL/6 mice alters transcriptome profiles in triple-negative breast cancer (TNBC) cells, leading to upregulation of genes involved in inflammation and lipid metabolism, such as
Identifiants
pubmed: 32859692
pii: 1541-7786.MCR-19-1223
doi: 10.1158/1541-7786.MCR-19-1223
doi:
Substances chimiques
ANGPTL4 protein, human
0
Angiopoietin-Like Protein 4
0
PPAR alpha
0
PPARA protein, human
0
Focal Adhesion Kinase 1
EC 2.7.10.2
PTK2 protein, human
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1849-1862Informations de copyright
©2020 American Association for Cancer Research.
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