First-in-Human Evaluation of
PET
SV2A
brain imaging
kinetic modeling
synaptic density
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
08
05
2020
accepted:
29
07
2020
pubmed:
30
8
2020
medline:
12
5
2021
entrez:
30
8
2020
Statut:
ppublish
Résumé
The use of synaptic vesicle glycoprotein 2A radiotracers with PET imaging could provide a way to measure synaptic density quantitatively in living humans.
Identifiants
pubmed: 32859701
pii: jnumed.120.249144
doi: 10.2967/jnumed.120.249144
pmc: PMC8049363
doi:
Substances chimiques
1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
0
GP2 protein, human
0
GPI-Linked Proteins
0
Ligands
0
Pyridines
0
Pyrrolidinones
0
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
561-567Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066508
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024139
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG065474
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052560
Pays : United States
Informations de copyright
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.
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