Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease.
Animals
Calcium
/ metabolism
Calcium Channels, L-Type
/ metabolism
Cardiomyopathy, Hypertrophic
/ drug therapy
Disease Models, Animal
Humans
Male
Membrane Potential, Mitochondrial
/ drug effects
Mice
Mice, Inbred BALB C
Mice, Nude
Mutation
/ genetics
Myocardium
/ metabolism
Myocytes, Cardiac
/ drug effects
Peptides
/ pharmacology
Troponin I
/ metabolism
L-type calcium channel
hypertrophic cardiomypathy
mitochondria
therapy
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
pubmed:
30
8
2020
medline:
27
10
2020
entrez:
30
8
2020
Statut:
ppublish
Résumé
Currently there is an unmet need for treatments that can prevent hypertrophic cardiomyopathy (HCM). Using a murine model we previously identified that HCM causing cardiac troponin I mutation Gly203Ser (
Identifiants
pubmed: 32859761
pii: 2002976117
doi: 10.1073/pnas.2002976117
pmc: PMC7502707
doi:
Substances chimiques
Calcium Channels, L-Type
0
Peptides
0
Troponin I
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23113-23124Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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