Impaired UTP-induced relaxation in the carotid arteries of spontaneously hypertensive rats.
Carotid artery
Hypertension
P2Y2
Relaxation
UTP
Journal
Purinergic signalling
ISSN: 1573-9546
Titre abrégé: Purinergic Signal
Pays: Netherlands
ID NLM: 101250499
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
09
03
2020
accepted:
10
08
2020
pubmed:
31
8
2020
medline:
19
8
2021
entrez:
31
8
2020
Statut:
ppublish
Résumé
Uridine 5'-triphosphate (UTP) has an important role as an extracellular signaling molecule that regulates inflammation, angiogenesis, and vascular tone. While chronic hypertension has been shown to promote alterations in arterial vascular tone regulation, carotid artery responses to UTP under hypertensive conditions have remained unclear. The present study investigated carotid artery responses to UTP in spontaneously hypertensive rats (SHR) and control Wistar Kyoto rats (WKY). Accordingly, our results found that although UTP promotes concentration-dependent relaxation in isolated carotid artery segments from both SHR and WKY after pretreatment with phenylephrine, SHR exhibited significantly lower arterial relaxation responses compared with WKY. Moreover, UTP-induced relaxation was substantially reduced by endothelial denudation and by the nitric oxide (NO) synthase inhibitor N
Identifiants
pubmed: 32862324
doi: 10.1007/s11302-020-09721-2
pii: 10.1007/s11302-020-09721-2
pmc: PMC7524952
doi:
Substances chimiques
ARC 118925XX
0
Furans
0
Piperidines
0
Purinergic P2Y Receptor Antagonists
0
Tetrazoles
0
Uridine Triphosphate
UT0S826Z60
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
453-461Références
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