Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca
HA helix
S4-S5 linker
SK2 channels
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
01
06
2020
revised:
09
08
2020
accepted:
20
08
2020
pubmed:
1
9
2020
medline:
19
8
2021
entrez:
1
9
2020
Statut:
ppublish
Résumé
Small-conductance Ca Site-directed mutagenesis, electrophysiological recordings and molecular dynamic (MD) simulations were utilized. Mutations that decrease hydrophobicity at the HA-S4-S5 interface lead to Ca The electrophysiological data and MD simulations collectively suggest a crucial role of the interactions between the HA helix and S4-S5 linker in the apparent Ca
Identifiants
pubmed: 32865319
doi: 10.1111/apha.13552
pmc: PMC7736289
mid: NIHMS1626265
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13552Subventions
Organisme : NINDS NIH HHS
ID : R21 NS101182
Pays : United States
Organisme : NINDS NIH HHS
ID : R33 NS101182
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
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