UV-type specific alteration of miRNA expression and its association with tumor progression and metastasis in SCC cell lines.
Carcinoma, Squamous Cell
/ genetics
Cell Line, Tumor
Cell Proliferation
/ genetics
Disease Progression
Epithelial-Mesenchymal Transition
/ genetics
Gene Expression Regulation, Neoplastic
/ radiation effects
Humans
MicroRNAs
/ genetics
Neoplasm Metastasis
Skin Neoplasms
/ etiology
Ultraviolet Rays
/ adverse effects
Cutaneous squamous cell carcinoma (cSCC)
Metastasis
Skin cancer
UV radiation
cSCC cell lines
miRNAs
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
18
12
2019
accepted:
18
08
2020
pubmed:
1
9
2020
medline:
15
12
2020
entrez:
1
9
2020
Statut:
ppublish
Résumé
UV exposure is the main risk factor for development of cutaneous squamous cell carcinoma (cSCC). While early detection greatly improves cSCC prognosis, locally advanced or metastatic cSCC has a severely impaired prognosis. Notably, the mechanisms of progression to metastatic cSCC are not well understood. We hypothesized that UV exposure of already transformed epithelial cSCC cells further induces changes which might be involved in the progression to metastatic cSCCs and that UV-inducible microRNAs (miRNAs) might play an important role. Thus, we analyzed the impact of UV radiation of different quality (UVA, UVB, UVA + UVB) on the miRNA expression pattern in established cell lines generated from primary and metastatic cSCCs (Met-1, Met-4) using the NanoString nCounter platform. This analysis revealed that the expression pattern of miRNAs depends on both the cell line used per se and on the quality of UV radiation. Comparison of UV-induced miRNAs in cSCC cell lines established from a primary tumor (Met-1) and the respective (un-irradiated) metastasis (Met-4) suggest that miR-7-5p, miR-29a-3p and miR-183-5p are involved in a UV-driven pathway of progression to metastasis. This notion is supported by the fact that these three miRNAs build up a network of 81 potential target genes involved e.g. in UVA/UVB-induced MAPK signaling and regulation of the epithelial-mesenchymal transition. As an example, PTEN, a target of UV-upregulated miRNAs (miR-29a-3p, miR-183-5p), could be shown to be down-regulated in response to UV radiation. We further identified CNOT8, the transcription complex subunit 8 of the CCR4-NOT complex, a deadenylase removing the poly(A) tail from miRNA-destabilized mRNAs, in the center of this network, targeted by all three miRNAs. In summary, our results demonstrate that UV radiation induces an miRNA expression pattern in primary SCC cell line partly resembling those of metastatic cell line, thus suggesting that UV radiation impacts SCC progression beyond initiation.
Identifiants
pubmed: 32865618
doi: 10.1007/s00432-020-03358-9
pii: 10.1007/s00432-020-03358-9
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3215-3231Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 02NUK036B
Organisme : Hiege-Stiftung gegen Hautkrebs
ID : D/106-21076
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