Rethinking amblyopia 2020.
Amblyopia
Mechanisms
Perceptual learning
Sensitive periods
Stereopsis
Videogames
Visual acuity
Journal
Vision research
ISSN: 1878-5646
Titre abrégé: Vision Res
Pays: England
ID NLM: 0417402
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
27
05
2020
revised:
30
07
2020
accepted:
31
07
2020
pubmed:
1
9
2020
medline:
26
11
2021
entrez:
1
9
2020
Statut:
ppublish
Résumé
Recent work has transformed our ideas about the neural mechanisms, behavioral consequences and effective therapies for amblyopia. Since the 1700's, the clinical treatment for amblyopia has consisted of patching or penalizing the strong eye, to force the "lazy" amblyopic eye, to work. This treatment has generally been limited to infants and young children during a sensitive period of development. Over the last 20 years we have learned much about the nature and neural mechanisms underlying the loss of spatial and binocular vision in amblyopia, and that a degree of neural plasticity persists well beyond the sensitive period. Importantly, the last decade has seen a resurgence of research into new approaches to the treatment of amblyopia both in children and adults, which emphasize that monocular therapies may not be the most effective for the fundamentally binocular disorder that is amblyopia. These approaches include perceptual learning, video game play and binocular methods aimed at reducing inhibition of the amblyopic eye by the strong fellow eye, and enhancing binocular fusion and stereopsis. This review focuses on the what we've learned over the past 20 years or so, and will highlight both the successes of these new treatment approaches in labs around the world, and their failures in clinical trials. Reconciling these results raises important new questions that may help to focus future directions.
Identifiants
pubmed: 32866759
pii: S0042-6989(20)30134-6
doi: 10.1016/j.visres.2020.07.014
pmc: PMC7487000
mid: NIHMS1622781
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118-129Subventions
Organisme : NEI NIH HHS
ID : R01 EY001728
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY020976
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY030609
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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