Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children.
ASD
Illumina
Nanostring
TaqMan assays
correlations
dysbiosis
microRNA
oral cavity
oral microbiota
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Aug 2020
27 Aug 2020
Historique:
received:
14
07
2020
revised:
16
08
2020
accepted:
25
08
2020
entrez:
2
9
2020
pubmed:
2
9
2020
medline:
26
2
2021
Statut:
epublish
Résumé
Recent evidence has demonstrated that salivary molecules, as well as bacterial populations, can be perturbed by several pathological conditions, including neuro-psychiatric diseases. This relationship between brain functionality and saliva composition could be exploited to unveil new pathological mechanisms of elusive diseases, such as Autistic Spectrum Disorder (ASD). We performed a combined approach of miRNA expression profiling by NanoString technology, followed by validation experiments in qPCR, and 16S rRNA microbiome analysis on saliva from 53 ASD and 27 neurologically unaffected control (NUC) children. MiR-29a-3p and miR-141-3p were upregulated, while miR-16-5p, let-7b-5p, and miR-451a were downregulated in ASD compared to NUCs. Microbiome analysis on the same subjects revealed that
Identifiants
pubmed: 32867322
pii: ijms21176203
doi: 10.3390/ijms21176203
pmc: PMC7504581
pii:
doi:
Substances chimiques
MIRN141 microRNA, human
0
MIRN16 microRNA, human
0
MIRN29a microRNA, human
0
MIRN451 microRNA, human
0
MicroRNAs
0
RNA, Ribosomal, 16S
0
mirnlet7 microRNA, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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