A Novel Peptide Antibiotic, Pro10-1D, Designed from Insect Defensin Shows Antibacterial and Anti-Inflammatory Activities in Sepsis Models.

Acinetobacter baumannii / drug effects Animals Antimicrobial Cationic Peptides / administration & dosage Cell Membrane / drug effects Coleoptera / metabolism Defensins / chemistry Disease Models, Animal Drug Resistance, Multiple, Bacterial / drug effects Drug Stability Escherichia coli / drug effects Escherichia coli Infections / drug therapy Female Insect Proteins / chemistry Lipopolysaccharides / adverse effects Mice Microbial Sensitivity Tests NF-kappa B / metabolism RAW 264.7 Cells Shock / drug therapy Signal Transduction / drug effects Toll-Like Receptor 4 / metabolism
antimicrobial peptide biofilm gram-negative infection peptide antibiotics sepsis

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
27 Aug 2020
Historique:
received: 24 07 2020
revised: 19 08 2020
accepted: 25 08 2020
entrez: 2 9 2020
pubmed: 2 9 2020
medline: 26 2 2021
Statut: epublish

Résumé

Owing to the challenges faced by conventional therapeutics, novel peptide antibiotics against multidrug-resistant (MDR) gram-negative bacteria need to be urgently developed. We had previously designed Pro9-3 and Pro9-3D from the defensin of beetle

Identifiants

DOI: 10.3390/ijms21176216 PMID: 32867384 PMC: PMC7504360
pubmed: 32867384
pii: ijms21176216
doi: 10.3390/ijms21176216
pmc: PMC7504360
pii:
doi:

Substances chimiques

Antimicrobial Cationic Peptides 0
Defensins 0
Insect Proteins 0
Lipopolysaccharides 0
NF-kappa B 0
Tlr4 protein, mouse 0
Toll-Like Receptor 4 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Research Foundation of Korea
ID : 2020R1A2C2005338.

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Auteurs

Manigandan Krishnan (M)

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea.

Joonhyeok Choi (J)

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea.

Ahjin Jang (A)

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea.

Yangmee Kim (Y)

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea.
ORCID: 0000-0001-6438-4718

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Classifications MeSH

questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Moraxellaceae › Acinetobacter › Acinetobacter baumannii › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Eucaryotes › Animaux › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Coléoptères › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Défensines › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Escherichia coli › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › A Novel Peptide Antibiotic, Pro10-1D, Designed...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-4 › A Novel Peptide Antibiotic, Pro10-1D, Designed...