The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review.
Cyclooxygenase 2
/ genetics
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation
Genetic Markers
Histone Code
Histones
/ metabolism
Humans
Interferon-gamma
/ genetics
Interleukin-6
/ genetics
Periodontal Diseases
/ genetics
Receptors, Interleukin-6
/ genetics
Suppressor of Cytokine Signaling 1 Protein
/ genetics
Tumor Necrosis Factor-alpha
/ genetics
DNA methylation
epigenetics
gene expression
gingival diseases
gingivitis
histone modification
periodontal diseases
periodontitis
systematic review
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Aug 2020
27 Aug 2020
Historique:
received:
08
07
2020
revised:
08
08
2020
accepted:
11
08
2020
entrez:
2
9
2020
pubmed:
2
9
2020
medline:
26
2
2021
Statut:
epublish
Résumé
Despite a number of reports in the literature on the role of epigenetic mechanisms in periodontal disease, a thorough assessment of the published studies is warranted to better comprehend the evidence on the relationship between epigenetic changes and periodontal disease and its treatment. Therefore, the aim of this systematic review is to identify and synthesize the evidence for an association between DNA methylation/histone modification and periodontal disease and its treatment in human adults. A systematic search was independently conducted to identify articles meeting the inclusion criteria. DNA methylation and histone modifications associated with periodontal diseases, gene expression, epigenetic changes after periodontal therapy, and the association between epigenetics and clinical parameters were evaluated. Sixteen studies were identified. All included studies examined DNA modifications in relation to periodontitis, and none of the studies examined histone modifications. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology, was found. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal disease.
Identifiants
pubmed: 32867386
pii: ijms21176217
doi: 10.3390/ijms21176217
pmc: PMC7503325
pii:
doi:
Substances chimiques
Genetic Markers
0
Histones
0
IFNG protein, human
0
IL6 protein, human
0
IL6R protein, human
0
Interleukin-6
0
Receptors, Interleukin-6
0
SOCS1 protein, human
0
Suppressor of Cytokine Signaling 1 Protein
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Cyclooxygenase 2
EC 1.14.99.1
PTGS2 protein, human
EC 1.14.99.1
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
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