Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children.

Brain / physiopathology Child Cognitive Dysfunction / etiology Cohort Studies Female Humans Male Mental Disorders / etiology Nausea / etiology Pregnancy Pregnancy Complications / etiology Vomiting / etiology
Cingulate cortex Cognitive performance Cortical structure Nausea and vomiting Precuneus Psychiatric problems Superior medial prefrontal cortex

Journal

BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723

Informations de publication

Date de publication:
01 09 2020
Historique:
received: 23 03 2020
accepted: 08 07 2020
entrez: 2 9 2020
pubmed: 2 9 2020
medline: 11 2 2021
Statut: epublish

Résumé

Two studies have suggested that severe prolonged nausea and vomiting during pregnancy is associated with emotional and behavioral problems in offspring, with smaller sample size and short-term follow-up. Moreover, little information is available on the role of the brain structure in the associations. In a US-based cohort, the association was investigated between severe prolonged nausea and vomiting in pregnancy (extending after the second trimester and termed SNVP), psychiatric and cognitive problems, and brain morphology, from the Adolescent Brain Cognitive Development (ABCD) study, from 10,710 children aged 9-11 years. We validated the emotional including psychiatric findings using the Danish National Cohort Study with 2,092,897 participants. SNVP was significantly associated with emotional and psychiatric problems (t = 8.89, Cohen's d = 0.172, p = 6.9 × 10 SNVP is strongly associated with psychiatric and cognitive problems in children, with mediation by brain structure. These associations highlight the clinical importance and potential benefits of the treatment of SNVP, which could reduce the risk of psychiatric disorder in the next generation.

Sections du résumé

BACKGROUND
Two studies have suggested that severe prolonged nausea and vomiting during pregnancy is associated with emotional and behavioral problems in offspring, with smaller sample size and short-term follow-up. Moreover, little information is available on the role of the brain structure in the associations.
METHODS
In a US-based cohort, the association was investigated between severe prolonged nausea and vomiting in pregnancy (extending after the second trimester and termed SNVP), psychiatric and cognitive problems, and brain morphology, from the Adolescent Brain Cognitive Development (ABCD) study, from 10,710 children aged 9-11 years. We validated the emotional including psychiatric findings using the Danish National Cohort Study with 2,092,897 participants.
RESULTS
SNVP was significantly associated with emotional and psychiatric problems (t = 8.89, Cohen's d = 0.172, p = 6.9 × 10
CONCLUSIONS
SNVP is strongly associated with psychiatric and cognitive problems in children, with mediation by brain structure. These associations highlight the clinical importance and potential benefits of the treatment of SNVP, which could reduce the risk of psychiatric disorder in the next generation.

Identifiants

DOI: 10.1186/s12916-020-01701-y PMID: 32867775 PMC: PMC7460800
pubmed: 32867775
doi: 10.1186/s12916-020-01701-y
pii: 10.1186/s12916-020-01701-y
pmc: PMC7460800
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

228

Subventions

Organisme : National Natural Science Foundation of China
ID : No.81701773; No.11771010
Pays : International
Organisme : National Natural Science Foundation of China
ID : No. 81571031, No. 81761128035, No.81701334, No. 81703249
Pays : International
Organisme : Shanghai Science and Technology Innovation Plan
ID : No. 15JC1400101 and No. 16JC1420402
Pays : International

Références

Lancet. 2019 Nov 16;394(10211):1827-1835
pubmed: 31668728
Mol Psychiatry. 2021 Aug;26(8):3992-4003
pubmed: 32015467
Scand J Public Health. 2011 Jul;39(7 Suppl):54-7
pubmed: 21775352
Psychoneuroendocrinology. 2010 Jan;35(1):141-53
pubmed: 19674845
Monogr Soc Res Child Dev. 2013 Aug;78(4):49-69
pubmed: 23952202
Scand J Public Health. 2011 Jul;39(7 Suppl):95-8
pubmed: 21775363
Neuroimage. 2010 Oct 15;53(1):1-15
pubmed: 20547229
Curr Opin Neurobiol. 2015 Feb;30:106-11
pubmed: 25500059
Cereb Cortex. 2015 Aug;25(8):2204-12
pubmed: 24591525
Hum Reprod. 2020 May 1;35(5):1211-1221
pubmed: 32340041
Dev Cogn Neurosci. 2018 Aug;32:8-15
pubmed: 29706313
Neurosci Lett. 2004 May 6;361(1-3):111-4
pubmed: 15135906
Am J Obstet Gynecol. 1989 Jan;160(1):247-51
pubmed: 2563197
Pediatrics. 2008 Apr;121(4):741-50
pubmed: 18381539
J Res Adolesc. 2018 Mar;28(1):154-156
pubmed: 29460352
J Am Acad Child Adolesc Psychiatry. 2012 Apr;51(4):356-67
pubmed: 22449642
Paediatr Perinat Epidemiol. 2014 Nov;28(6):527-35
pubmed: 25327160
Am J Obstet Gynecol. 2002 May;186(5 Suppl Understanding):S220-7
pubmed: 12011890
JAMA Psychiatry. 2015 Jun;72(6):531-40
pubmed: 25807066
Dev Cogn Neurosci. 2018 Aug;32:43-54
pubmed: 29567376
J Neurosci. 2011 Aug 10;31(32):11505-14
pubmed: 21832180
Neuron. 2016 May 18;90(4):692-707
pubmed: 27196973
JAMA. 1999 Aug 4;282(5):455-62
pubmed: 10442661
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16841-6
pubmed: 19805383
Biol Psychiatry. 2018 May 15;83(10):886-894
pubmed: 29198470
Biol Psychiatry. 2015 Feb 15;77(4):324-34
pubmed: 25129235
Int J Epidemiol. 2016 Dec 1;45(6):1866-1886
pubmed: 28108528
JAMA Psychiatry. 2014 May;71(5):573-81
pubmed: 24806211
Hum Brain Mapp. 2015 Jun;36(6):2318-29
pubmed: 25711175
Cereb Cortex. 2019 Jul 22;29(8):3617-3630
pubmed: 30418547
Mol Autism. 2018 Jun 19;9:37
pubmed: 29951183
JAMA Psychiatry. 2017 Apr 1;74(4):339-349
pubmed: 28241183
BMC Pregnancy Childbirth. 2018 Jun 27;18(1):268
pubmed: 29945561
Hum Brain Mapp. 2022 Jan;43(1):37-55
pubmed: 32420680
Dialogues Clin Neurosci. 2013 Sep;15(3):359-84
pubmed: 24174907
Eur J Epidemiol. 2018 Jan;33(1):27-36
pubmed: 29349587
Mol Psychiatry. 2022 Feb;27(2):967-975
pubmed: 34650205
Neurology. 2013 Mar 12;80(11 Suppl 3):S2-6
pubmed: 23479538
JAMA Psychiatry. 2016 Aug 1;73(8):815-825
pubmed: 27276220
JAMA Intern Med. 2016 Nov 1;176(11):1621-1627
pubmed: 27669539
Brain. 2006 Mar;129(Pt 3):564-83
pubmed: 16399806
J Pers Soc Psychol. 1986 Dec;51(6):1173-82
pubmed: 3806354
Brain Struct Funct. 2019 Dec;224(9):3001-3018
pubmed: 31451898
Neuroimage. 2019 Nov 15;202:116091
pubmed: 31415884
Neuropsychopharmacology. 2008 Apr;33(5):1019-27
pubmed: 17609681
Neuron. 2008 Sep 25;59(6):1037-50
pubmed: 18817740
Reprod Toxicol. 2019 Mar;84:59-64
pubmed: 30594672
Child Adolesc Psychiatry Ment Health. 2019 Jul 5;13:30
pubmed: 31312253
Am J Obstet Gynecol. 2000 Apr;182(4):931-7
pubmed: 10764476
Neurosci Biobehav Rev. 2020 Oct;117:26-64
pubmed: 28757456
Dev Neurosci. 2009;31(4):285-92
pubmed: 19546565
BMC Med. 2020 Apr 1;18(1):96
pubmed: 32238167
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Dec;3(12):1040-1049
pubmed: 30243643
JAMA Psychiatry. 2019 Jul 1;76(7):762-764
pubmed: 30916716
Dev Cogn Neurosci. 2018 Aug;32:55-66
pubmed: 29113758
Transl Psychiatry. 2018 Nov 29;8(1):261
pubmed: 30498214
Neuroimage. 2019 Jan 15;185:140-153
pubmed: 30339913
Neuroimage. 2017 Jun;153:246-261
pubmed: 28392489
Biol Psychiatry. 2019 Jan 15;85(2):135-149
pubmed: 30057177
Clin Epidemiol. 2015 Nov 17;7:449-90
pubmed: 26604824
Eur J Epidemiol. 2014 Aug;29(8):541-9
pubmed: 24965263
J Neurosci. 2012 Oct 31;32(44):15243-51
pubmed: 23115162
Dev Cogn Neurosci. 2018 Aug;32:16-22
pubmed: 29703560
Neuropsychopharmacology. 2008 Feb;33(3):536-45
pubmed: 17507916
J Neurosci. 2013 Sep 18;33(38):15120-5
pubmed: 24048842
BMC Pregnancy Childbirth. 2015 Jun 23;15:138
pubmed: 26100060
Scand J Public Health. 2011 Jul;39(7 Suppl):30-3
pubmed: 21775347
Hum Reprod Update. 2005 Sep-Oct;11(5):527-39
pubmed: 16006438
Brain. 2015 May;138(Pt 5):1382-93
pubmed: 25795704
Cortex. 2016 Sep;82:1-10
pubmed: 27268101
Scand J Public Health. 2011 Jul;39(7 Suppl):38-41
pubmed: 21775349
N Engl J Med. 2010 Oct 14;363(16):1544-50
pubmed: 20942670
Am J Psychiatry. 2018 May 1;175(5):471-479
pubmed: 29495899
PLoS One. 2011;6(11):e27678
pubmed: 22125621
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 May;4(5):484-492
pubmed: 30905689
JAMA Psychiatry. 2020 Aug 1;77(8):797-805
pubmed: 32211833
Nat Hum Behav. 2019 Jul;3(7):692-701
pubmed: 31110341
Am J Perinatol. 2021 Feb;38(3):265-272
pubmed: 31581303
Psychoneuroendocrinology. 2016 May;67:10-7
pubmed: 26855003
Curr Biol. 2008 Feb 12;18(3):R110-4
pubmed: 18269902
Cell Death Differ. 2010 Jul;17(7):1092-103
pubmed: 20019745

Auteurs

Hui Wang (H)

Department of Developmental and Behavioral Pediatric & Child Primary Care/MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Edmund T Rolls (ET)

Institute of Science and Technology for Brain-inspired intelligence, Fudan University, Shanghai, China.
Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK.
Oxford Centre for Computational Neuroscience, Oxford, OX1 4BH, UK.

Xiujuan Du (X)

Department of Developmental and Behavioral Pediatric & Child Primary Care/MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Jingnan Du (J)

Institute of Science and Technology for Brain-inspired intelligence, Fudan University, Shanghai, China.

Dexin Yang (D)

Institute of Science and Technology for Brain-inspired intelligence, Fudan University, Shanghai, China.

Jiong Li (J)

Department of Developmental and Behavioral Pediatric & Child Primary Care/MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.

Fei Li (F)

Department of Developmental and Behavioral Pediatric & Child Primary Care/MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. feili@shsmu.edu.cn.

Wei Cheng (W)

Institute of Science and Technology for Brain-inspired intelligence, Fudan University, Shanghai, China. wcheng@fudan.edu.cn.
Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Fudan University, Shanghai, China. wcheng@fudan.edu.cn.

Jianfeng Feng (J)

Institute of Science and Technology for Brain-inspired intelligence, Fudan University, Shanghai, China.
Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Fudan University, Shanghai, China.
Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › Troubles mentaux › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Nausée › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Severe nausea and vomiting in pregnancy:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Vomissement › Severe nausea and vomiting in pregnancy:...