ABHD4-dependent developmental anoikis safeguards the embryonic brain.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 08 2020
31 08 2020
Historique:
received:
28
11
2019
accepted:
03
08
2020
entrez:
2
9
2020
pubmed:
2
9
2020
medline:
17
9
2020
Statut:
epublish
Résumé
A specialized neurogenic niche along the ventricles accumulates millions of progenitor cells in the developing brain. After mitosis, fate-committed daughter cells delaminate from this germinative zone. Considering the high number of cell divisions and delaminations taking place during embryonic development, brain malformations caused by ectopic proliferation of misplaced progenitor cells are relatively rare. Here, we report that a process we term developmental anoikis distinguishes the pathological detachment of progenitor cells from the normal delamination of daughter neuroblasts in the developing mouse neocortex. We identify the endocannabinoid-metabolizing enzyme abhydrolase domain containing 4 (ABHD4) as an essential mediator for the elimination of pathologically detached cells. Consequently, rapid ABHD4 downregulation is necessary for delaminated daughter neuroblasts to escape from anoikis. Moreover, ABHD4 is required for fetal alcohol-induced apoptosis, but not for the well-established form of developmentally controlled programmed cell death. These results suggest that ABHD4-mediated developmental anoikis specifically protects the embryonic brain from the consequences of sporadic delamination errors and teratogenic insults.
Identifiants
pubmed: 32868797
doi: 10.1038/s41467-020-18175-4
pii: 10.1038/s41467-020-18175-4
pmc: PMC7459116
doi:
Substances chimiques
ABHD4 protein, human
EC 3.1.1.-
Lysophospholipase
EC 3.1.1.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4363Subventions
Organisme : NINDS NIH HHS
ID : R01 NS099457
Pays : United States
Organisme : NIH HHS
ID : S10 OD025279
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA033760
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA011322
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA044925
Pays : United States
Organisme : NIDA NIH HHS
ID : K05 DA021696
Pays : United States
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