Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells.
Animals
Chlorhexidine
/ analogs & derivatives
Epithelial Cells
/ drug effects
Epithelial-Mesenchymal Transition
/ drug effects
Male
Mice
Mice, Inbred C57BL
Myofibroblasts
/ drug effects
Peritoneal Fibrosis
/ chemically induced
Snail Family Transcription Factors
/ metabolism
Trehalose
/ therapeutic use
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
31 08 2020
31 08 2020
Historique:
received:
27
04
2018
accepted:
12
08
2020
entrez:
2
9
2020
pubmed:
2
9
2020
medline:
24
2
2021
Statut:
epublish
Résumé
Peritoneal fibrosis (PF) is a severe complication of peritoneal dialysis, but there are few effective therapies for it. Recent studies have revealed a new biological function of trehalose as an autophagy inducer. Thus far, there are few reports regarding the therapeutic effects of trehalose on fibrotic diseases. Therefore, we examined whether trehalose has anti-fibrotic effects on PF. PF was induced by intraperitoneal injection of chlorhexidine gluconate (CG). CG challenges induced the increase of peritoneal thickness, ColIα
Identifiants
pubmed: 32868830
doi: 10.1038/s41598-020-71230-4
pii: 10.1038/s41598-020-71230-4
pmc: PMC7459354
doi:
Substances chimiques
Snai1 protein, mouse
0
Snail Family Transcription Factors
0
Trehalose
B8WCK70T7I
chlorhexidine gluconate
MOR84MUD8E
Chlorhexidine
R4KO0DY52L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14292Références
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