Luteolin, a Potent Human Monoamine Oxidase-A Inhibitor and Dopamine D
Antidiuretic Hormone Receptor Antagonists
/ chemistry
Cirsium
/ chemistry
Humans
Kinetics
Luteolin
/ chemistry
Molecular Docking Simulation
Monoamine Oxidase
/ chemistry
Monoamine Oxidase Inhibitors
/ chemistry
Plant Extracts
/ chemistry
Receptors, Dopamine D4
/ antagonists & inhibitors
Receptors, Vasopressin
/ chemistry
GPCRs
dopamine
luteolin
molecular docking
vasopressin receptor
Journal
Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755
Informations de publication
Date de publication:
30 Sep 2020
30 Sep 2020
Historique:
pubmed:
2
9
2020
medline:
7
2
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
Luteolin, a flavonoid widely distributed in the plant kingdom, contains two benzene rings and hydroxyl groups, and this structural specificity contributes to its diverse biological activities. However, no previous studies have simultaneously investigated the therapeutic potency of luteolin isolated from a plant as an antipsychotic and antidepressant. Here, luteolin exhibited selective inhibition of hMAO-A (IC
Identifiants
pubmed: 32869630
doi: 10.1021/acs.jafc.0c04502
doi:
Substances chimiques
Antidiuretic Hormone Receptor Antagonists
0
Monoamine Oxidase Inhibitors
0
Plant Extracts
0
Receptors, Vasopressin
0
Receptors, Dopamine D4
137750-34-6
Monoamine Oxidase
EC 1.4.3.4
monoamine oxidase A, human
EC 1.4.3.4.
Luteolin
KUX1ZNC9J2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM