Non-severe haemophilia: Is it benign? - Insights from the PROBE study.
bleeding
haemophilia
pain
patient-reported outcome
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
ISSN: 1365-2516
Titre abrégé: Haemophilia
Pays: England
ID NLM: 9442916
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
12
03
2020
revised:
15
06
2020
accepted:
22
06
2020
pubmed:
2
9
2020
medline:
25
9
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
There are limited data on the impact of haemophilia on health status and health-related quality of life (HRQL) in people with non-severe (mild and moderate) haemophilia. To evaluate the health status of people living with mild or moderate haemophilia. Data on respondents with no bleeding disorder (NoBD), mild and moderate haemophilia patients were drawn from the PROBE study. Respondents were enrolled using network patient organizations. This analysis was performed as a cross-sectional study. Primary outcomes were reported bleeding, acute and chronic pain, activities of daily living and HRQL. A total of 862 respondents with NoBD (n = 173), mild (n = 102) and moderate (n = 134) haemophilia were eligible, with a median age of 33, 42 and 43, respectively. In relation to haemophilia-related sequalae, 53% of male and 29% of female patients with mild and 83% of males with moderate haemophilia had more than 2-3 bleeds in the last 12 months. Reporting of acute and chronic pain is less in those with NoBD compared to the mild and moderate cohorts for both genders. Multivariate analysis demonstrates significant reductions in quality of life using VAS, EQ-5D-5L and PROBE for males with mild and moderate haemophilia (P ≤ .001) with only PROBE indicating a significant reduction for females with mild (P = .002). People affected by mild or moderate haemophilia report a significant HRQL impact due to haemophilia-related bleeding. Future research is needed to identify the optimal care management of patients with mild and moderate haemophilia.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-24Subventions
Organisme : Bayer
Organisme : Takeda
Organisme : Sobi
Organisme : Roche
Organisme : Sanofi
Organisme : Novo Nordisk
Organisme : CSL Behring
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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