Preparation, Supramolecular Aggregation and Immunological Activity of the Bona Fide Vaccine Adjuvant Sulfavant S.
adjuvant
aggregates
colloid
immunomodulatory activity
sulfavants
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
29 Aug 2020
29 Aug 2020
Historique:
received:
20
07
2020
revised:
21
08
2020
accepted:
26
08
2020
entrez:
3
9
2020
pubmed:
3
9
2020
medline:
19
5
2021
Statut:
epublish
Résumé
In aqueous conditions, amphiphilic bioactive molecules are able to form self-assembled colloidal structures modifying their biological activity. This behavior is generally neglected in preclinical studies, despite its impact on pharmacological development. In this regard, a significative example is represented by a new class of amphiphilic marine-inspired vaccine adjuvants, collectively named Sulfavants, based on the β-sulfoquinovosyl-diacylglyceride skeleton. The family includes the lead product Sulfavant A (
Identifiants
pubmed: 32872423
pii: md18090451
doi: 10.3390/md18090451
pmc: PMC7551793
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Biomarkers
0
Colloids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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