Cardiovascular and Metabolic Responses to Carbon Dioxide Euthanasia in Conscious and Anesthetized Rats.
Journal
Journal of the American Association for Laboratory Animal Science : JAALAS
ISSN: 2769-6677
Titre abrégé: J Am Assoc Lab Anim Sci
Pays: United States
ID NLM: 101269489
Informations de publication
Date de publication:
01 11 2020
01 11 2020
Historique:
pubmed:
3
9
2020
medline:
4
2
2021
entrez:
3
9
2020
Statut:
ppublish
Résumé
Euthanasia is a necessary component in research and must be conducted humanely. Currently, regulated CO₂ exposure in conscious rats is acceptable, but data are divided on whether CO₂ alone is more distressing than anesthesia prior to CO₂. To evaluate distress in rats, we compared physiologic responses to CO₂ euthanasia with and without isoflurane preanesthesia. Male Sprague-Dawley rats were implanted with telemetry devices to measure mean arterial pressure (MAP), heart rate (HR), and blood glucose. Animals recovered for 2 wk and were then exposed to either 5% isoflurane (
Identifiants
pubmed: 32873368
doi: 10.30802/AALAS-JAALAS-19-000166
pmc: PMC7604681
doi:
Substances chimiques
Anesthetics, Inhalation
0
Carbon Dioxide
142M471B3J
Isoflurane
CYS9AKD70P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
742-749Références
Lab Anim. 2002 Apr;36(2):127-33
pubmed: 11943076
Lab Anim. 1997 Oct;31(4):337-46
pubmed: 9350705
Neuroscience. 2007 Jan 5;144(1):336-43
pubmed: 17049168
Lab Anim. 2016 Aug;50(4):241-53
pubmed: 26609130
Br J Anaesth. 1959 Apr;31(4):142-51
pubmed: 13651520
Lab Anim. 2005 Apr;39(2):137-61
pubmed: 15901358
Comp Med. 2002 Jun;52(3):249-57
pubmed: 12102571
J Am Assoc Lab Anim Sci. 2006 Mar;45(2):21-5
pubmed: 16542038
Lab Anim Sci. 1997 Aug;47(4):376-85
pubmed: 9306311
Behav Brain Res. 2016 May 15;305:122-5
pubmed: 26946276
Lab Anim (NY). 2016 Sep 21;45(10):386-95
pubmed: 27654690
Naunyn Schmiedebergs Arch Pharmacol. 1993 Aug;348(2):146-53
pubmed: 8232593
Lab Anim. 1988 Jan;22(1):67-75
pubmed: 3127635
Diabetes Metab Res Rev. 2020 Mar;36(3):e3229
pubmed: 31655012
J Clin Invest. 1984 Aug;74(2):321-31
pubmed: 6547729
Endocr Rev. 2000 Feb;21(1):55-89
pubmed: 10696570
J Am Assoc Lab Anim Sci. 2010 Jul;49(4):448-53
pubmed: 20819391
Fed Proc. 1984 Jan;43(1):32-8
pubmed: 6317463
J Am Assoc Lab Anim Sci. 2006 Jan;45(1):98-105
pubmed: 16548095
PLoS One. 2017 Jun 15;12(6):e0179588
pubmed: 28617851
Animals (Basel). 2016 Aug 02;6(8):
pubmed: 27490573
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10685-90
pubmed: 17563364
J Am Assoc Lab Anim Sci. 2016;55(4):451-61
pubmed: 27423153
Neuroendocrinology. 1989 May;49(5):496-501
pubmed: 2542831
Physiol Res. 2010;59(6):973-8
pubmed: 20533863
J Am Assoc Lab Anim Sci. 2006 May;45(3):17-22
pubmed: 16642965
Front Cardiovasc Med. 2016 Jul 29;3:23
pubmed: 27525256
Lab Anim. 1999 Apr;33(2):155-61
pubmed: 10780819
Prog Neuropsychopharmacol Biol Psychiatry. 1993 Jul;17(4):651-61
pubmed: 7689736
Behav Brain Funct. 2008 Jun 02;4:23
pubmed: 18518967
J Am Assoc Lab Anim Sci. 2018 Oct 10;:
pubmed: 30305196
Comp Med. 2007 Dec;57(6):570-3
pubmed: 18246869
Neurosci Lett. 1985 Nov 20;62(1):51-6
pubmed: 4069453
Brain Res. 1994 Mar 21;640(1-2):322-7
pubmed: 8004460
Compr Physiol. 2016 Mar 15;6(2):603-21
pubmed: 27065163
Biol Lett. 2012 Dec 19;9(1):20121000
pubmed: 23256183
Lab Anim. 2000 Jan;34(1):91-6
pubmed: 10759372
Curr Neuropharmacol. 2010 Mar;8(1):2-9
pubmed: 20808541
PLoS One. 2016 Sep 20;11(9):e0162639
pubmed: 27648836
Endocrinology. 2009 Jun;150(6):2934-9
pubmed: 19213839
Contemp Top Lab Anim Sci. 2001 Sep;40(5):22-4
pubmed: 11560401
J Am Assoc Lab Anim Sci. 2012 Jan;51(1):50-7
pubmed: 22330868
J Physiol. 2016 Sep 1;594(17):4967-80
pubmed: 27061304
J Appl Physiol. 1964 Nov;19:1151-6
pubmed: 14232312
Basic Clin Pharmacol Toxicol. 2017 Aug;121(2):113-118
pubmed: 28244216