Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
03
04
2019
accepted:
06
08
2020
revised:
25
07
2020
pubmed:
3
9
2020
medline:
28
1
2022
entrez:
3
9
2020
Statut:
ppublish
Résumé
Depression is one of the global leading causes of disability, but treatments remain limited and classical antidepressants were found to be ineffective in a substantial proportion of patients. Thus, novel effective therapies for the treatment of depression are urgently needed. Given the emerging role of inflammation in the etiology and pathophysiology of affective disorders, we herein illustrate how experimental endotoxemia, a translational model of systemic inflammation, could be used as a tool to develop and test new therapeutic options against depression. Our concept is based on the striking overlap of inflammatory, neural, and affective characteristics in patients with inflammation-associated depression and in endotoxin-challenged healthy subjects. Experimental administration of endotoxin in healthy volunteers is safe, well-tolerated, and without known long-term health risks. It offers a highly standardized translational approach to characterize potential targets of therapies against inflammation-associated depression, as well as to identify characteristics of patients that would benefit from these interventions, and, therefore, could contribute to improve personalization of treatment and to increase the overall rate of responders.
Identifiants
pubmed: 32873895
doi: 10.1038/s41380-020-00869-2
pii: 10.1038/s41380-020-00869-2
pmc: PMC8550942
doi:
Substances chimiques
Endotoxins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3672-3683Informations de copyright
© 2020. The Author(s).
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