Can Oocyte Diameter Predict Embryo Quality?
ART
Blastocyst grading
Fertility preservation
In vitro fertilization
Intracytoplasmic sperm injection
Oocyte diameter
Vitrification
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
14
03
2020
accepted:
25
08
2020
pubmed:
3
9
2020
medline:
24
11
2021
entrez:
3
9
2020
Statut:
ppublish
Résumé
With the recent increased utilization of oocyte vitrification for the purpose of fertility preservation, information regarding the future fertility potential of the frozen oocytes is mandatory. Nowadays, there is a relative lack of data about prediction of assisted reproductive technique (ART) success relying on the retrieved oocytes. In the present study, we therefore aimed to investigate whether oocyte diameter might predict the quality of the developing embryo. A retrospective, single-center cohort study. Oocytes retrieved following controlled ovarian hyperstimulation cycles during 2016 and incubated in a time-lapse incubator system were analyzed. Oocytes were grouped by mean oocyte diameter (MOD) and incubated for 5 days before the final morphological evaluation done by an expert embryologist. A total of 471 cycles which yielded 3355 metaphase II oocytes were included in the analysis. Embryos developed from oocytes with MOD close to the average (Average 1SD < MOD < Average + 1SD) had increased good-quality blastulation rates compared with embryos that developed from very small or very large oocytes. Oocytes with MOD between 105.96 and 118.69 μm have better probability of becoming top-quality D5 blastocysts (17.1-17.4% grade 1 embryos). There is a correlation between oocyte's MOD and the embryo quality at day 5. The oocytes with near average MOD have a better chance to develop to a good-quality embryo. Therefore, the study suggests that MOD might serve as a predictor for embryo grading at day 5.
Identifiants
pubmed: 32876908
doi: 10.1007/s43032-020-00306-3
pii: 10.1007/s43032-020-00306-3
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
904-908Références
Drakopoulos P, Blockeel C, Stoop D, Camus M, de Vos M, Tournaye H, et al. Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum Reprod. 2016;31(2):370–6.
pubmed: 26724797
Ebner T, Moser M, Tews G. Is oocyte morphology prognostic of embryo developmental potential after ICSI? Reprod BioMed Online. 2006;12:507–12.
doi: 10.1016/S1472-6483(10)62006-8
Loutradis D, Drakakis P, Kallianidis K, Milingos S, Dendrinos S, Michalas S. Oocyte morphology correlates with embryo quality and pregnancy rate after intracytoplasmic sperm injection. Fertil Steril. 1999;72:240–4.
doi: 10.1016/S0015-0282(99)00233-2
Meriano JS, Alexis J, Visram-Zaver S, Cruz M, Casper RF. Tracking of oocyte dysmorphisms for ICSI patients may prove relevant to the outcome in subsequent patient cycles. Hum Reprod. 2001;16:2118–23.
doi: 10.1093/humrep/16.10.2118
Otoi T, Fujii M, Tanaka M, Ooka A, Suzuki T. Canine oocyte diameter in relation to meiotic competence and sperm penetration. Theriogenology. 2000;54(4):535–42.
doi: 10.1016/S0093-691X(00)00368-X
Anguita B, Jimenez-Macedo AR, Izquierdo D, Mogas T, Paramio MT. Effect of oocyte diameter on meiotic competence, embryo development, p34 (cdc2) expression and MPF activity in prepubertal goat oocytes. Theriogenology. 2007;67:526–36.
doi: 10.1016/j.theriogenology.2006.09.003
Griffin J, Emery BR, Huang I, Peterson CM, Carrell DT. Comparative analysis of follicle morphology and oocyte diameter in four mammalian species (mouse, hamster, pig, and human). J Exp Clin Assist Reprod. 2006;3:1–9.
doi: 10.1186/1743-1050-3-2
Romão GS, Araújo MCPM, de Melo AS, Navarro PA d AS, Ferriani RA, dos Reis RM. Oocyte diameter as a predictor of fertilization and embryo quality in assisted reproduction cycles. Fertil Steril. 2010;93:621–5.
doi: 10.1016/j.fertnstert.2008.12.124
Heitmann RJ, Hill MJ, Richter KS, DeCherney AH, Widra EA. The simplified SART embryo scoring system is highly correlated to implantation and live birth in single blastocyst transfers. J Assist Reprod Genet. 2013;30:563–7.
doi: 10.1007/s10815-013-9932-1
Cobo A, García-Velasco JA, Coello A, Domingo J, Pellicer A, Remohí J. Oocyte vitrification as an efficient option for elective fertility preservation. Fertil Steril. 2016;105:755–764e8.
doi: 10.1016/j.fertnstert.2015.11.027
Stoop D, Cobo A, Silber S. Fertility preservation for age-related fertility decline. Lancet. 2014;384:1311–9.
doi: 10.1016/S0140-6736(14)61261-7
Silber SJ, Kato K, Aoyama N, Yabuuchi A, Skaletsky H, Fan Y, et al. Intrinsic fertility of human oocytes. Fertil Steril. 2017;107:1232–7.
doi: 10.1016/j.fertnstert.2017.03.014
Goldman RH, Racowsky C, Farland LV, Munné S, Ribustello L, Fox JH. Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients. Hum Reprod. 2017;32(4):853–9.
doi: 10.1093/humrep/dex008