Dendritic Mesoporous Silica Nanoparticle Adjuvants Modified with Binuclear Aluminum Complex: Coordination Chemistry Dictates Adjuvanticity.


Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
26 10 2020
Historique:
received: 12 05 2020
revised: 10 08 2020
pubmed: 3 9 2020
medline: 23 3 2021
entrez: 3 9 2020
Statut: ppublish

Résumé

Aluminum-containing adjuvants used in vaccine formulations suffer from low cellular immunity, severe aggregation, and accumulation in the brain. Conventional aluminosilicates widely used in the chemical industry focus mainly on acidic sites for catalytic applications, but they are rarely used as adjuvants. Reported here is an innovative "ligand-assisted steric hindrance" strategy to create a high density of six-coordinate

Identifiants

pubmed: 32876984
doi: 10.1002/anie.202006861
doi:

Substances chimiques

Adjuvants, Immunologic 0
Aluminum Silicates 0
Antigens 0
Coordination Complexes 0
Silicon Dioxide 7631-86-9
Ovalbumin 9006-59-1
Aluminum CPD4NFA903

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

19610-19617

Informations de copyright

© 2020 Wiley-VCH GmbH.

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Auteurs

Yang Yang (Y)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.

Jie Tang (J)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.

Hao Song (H)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.

Yannan Yang (Y)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.

Zhengying Gu (Z)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.

Jianye Fu (J)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.

Yang Liu (Y)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.

Min Zhang (M)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.

Zhen-An Qiao (ZA)

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, Jilin, 130012, China.

Chengzhong Yu (C)

Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.

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