RSV M2-1 Protein in Complex with RNA: Old Questions Are Answered and a New One Emerges.

Humans RNA Respiratory Syncytial Virus, Human / genetics Viral Proteins / genetics Virus Replication
M2-1 protein RNA-dependent RNA polymerase human metapneumovirus non-segmented negative strand RNA virus respiratory syncytial virus transcription

Journal

Structure (London, England : 1993)
ISSN: 1878-4186
Titre abrégé: Structure
Pays: United States
ID NLM: 101087697

Informations de publication

Date de publication:
01 09 2020
Historique:
entrez: 3 9 2020
pubmed: 3 9 2020
medline: 3 11 2020
Statut: ppublish

Résumé

The respiratory syncytial virus (RSV) M2-1 protein is essential for virus transcription. In this issue of Structure, Gao et al. (2020) describe the crystal structure of M2-1 in complex with RNA. This structure provides new insight into the RSV transcription mechanism but also raises an intriguing question regarding M2-1's function.

Identifiants

DOI: 10.1016/j.str.2020.08.007 PMID: 32877647
pubmed: 32877647
pii: S0969-2126(20)30289-6
doi: 10.1016/j.str.2020.08.007
pii:
doi:

Substances chimiques

Viral Proteins 0
RNA 63231-63-0

Types de publication

Journal Article Research Support, N.I.H., Extramural Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

977-978

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI113321
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133486
Pays : United States
Organisme : NHLBI NIH HHS
ID : R33 HL137081
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI147659
Pays : United States

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Victoria Anne Kleiner (VA)

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

Rachel Fearns (R)

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: rfearns@bu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › RSV M2-1 Protein in Complex with RNA: Old...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › RSV M2-1 Protein in Complex with RNA: Old...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Paramyxoviridae › Pneumovirinae › Pneumovirus › Virus respiratoires syncytiaux › Virus respiratoire syncytial humain › RSV M2-1 Protein in Complex with RNA: Old...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › RSV M2-1 Protein in Complex with RNA: Old...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › RSV M2-1 Protein in Complex with RNA: Old...