Rachel Fearns

Affiliations

Boston University School of Medicine, National Emerging Infectious Diseases Laboratories, Boston, MA, USA. rfearns@bu.edu.

Publications (22)

Structure of the human metapneumovirus polymerase phosphoprotein complex.

Nature

Avec: Junhua Pan , Xinlei Qian , Simon Lattmann , Abbas El Sahili , Tiong Han Yeo , Huan Jia , Tessa Cressey , Barbara Ludeke , Sarah Noton , Marian Kalocsay , Rachel Fearns , Julien Lescar

The Respiratory Syncytial Virus Polymerase: A Multitasking Machine.

Trends in microbiology

Avec: Rachel Fearns

Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance.

PloS one

Avec: I'ah Donovan-Banfield , Rachel Milligan , Sophie Hall , Tianyi Gao , Eleanor Murphy , Jack Li , Ghada T Shawli , Julian Hiscox , Xiaodong Zhuang , Jane A McKeating , Rachel Fearns , David A Matthews

Activation of STAT3-mediated ciliated cell survival protects against severe infection by respiratory syncytial virus.

The Journal of clinical investigation

Avec: Caiqi Zhao , Yan Bai , Wei Wang , Gaurang M Amonkar , Hongmei Mou , Judith Olejnik , Adam J Hume , Elke Mühlberger , Nicholas W Lukacs , Rachel Fearns , Paul H Lerou , Xingbin Ai

Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses.

PLoS pathogens

Avec: Tessa N Cressey , Afzaal M Shareef , Victoria A Kleiner , Sarah L Noton , Patrick O Byrne , Jason S McLellan , Elke Mühlberger , Rachel Fearns

Diversity of B Cell Populations and Ig Repertoire in Human Lungs.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Fumiaki Aihara , Yumei Wang , Anna C Belkina , Rachel Fearns , Joseph P Mizgerd , Feng Feng , Thomas B Kepler

JNJ-7184, a Respiratory Syncytial Virus inhibitor targeting the connector domain of the viral polymerase.

Antiviral research

Avec: Brecht Bonneux , Afzaal Shareef , Sergey Tcherniuk , Brandon Anson , Suzanne de Bruyn , Nick Verheyen , Kim Thys , Nádia Conceição-Neto , Marcia Van Ginderen , Leen Kwanten , Nina Ysebaert , Luc Vranckx , Elien Peeters , Ellen Lanckacker , Jack M Gallup , Panchan Sitthicharoenchai , Sarhad Alnajjar , Mark R Ackermann , Suraj Adhikari , Anusarka Bhaumik , Aaron Patrick , Amy Fung , Priscila Sutto-Ortiz , Etienne Decroly , Stephen W Mason , David Lançois , Jerome Deval , Zhinan Jin , Jean-François Eléouët , Rachel Fearns , Anil Koul , Dirk Roymans , Peter Rigaux , Florence Herschke

How does the polymerase of non-segmented negative strand RNA viruses commit to transcription or genome replication?

Journal of virology

Avec: Victoria A Kleiner , Rachel Fearns

Ebolavirus polymerase uses an unconventional genome replication mechanism.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Laure R Deflubé , Tessa N Cressey , Adam J Hume , Judith Olejnik , Elaine Haddock , Friederike Feldmann , Hideki Ebihara , Rachel Fearns , Elke Mühlberger

Structures and Mechanisms of Nonsegmented, Negative-Strand RNA Virus Polymerases.

Annual review of virology

Avec: Mohamed Ouizougun-Oubari , Rachel Fearns

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases.

Communications biology

Avec: Victoria A Kleiner , Thierry O Fischmann , John A Howe , Douglas C Beshore , Michael J Eddins , Yan Hou , Todd Mayhood , Daniel Klein , Debbie D Nahas , Bob J Lucas , He Xi , Edward Murray , Daphne Y Ma , Krista Getty , Rachel Fearns

RSV M2-1 Protein in Complex with RNA: Old Questions Are Answered and a New One Emerges.

Structure (London, England : 1993)

Avec: Victoria Anne Kleiner , Rachel Fearns

The respiratory syncytial virus polymerase can perform RNA synthesis with modified primers and nucleotide analogs.

Virology

Avec: Barbara Ludeke , Rachel Fearns

Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018.

Antiviral research

Avec: Athanase Badolo , Felicity Burt , Susan Daniel , Rachel Fearns , Eduardo Samo Gudo , Margaret Kielian , Julien Lescar , Yi Shi , Albrecht von Brunn , Susan R Weiss , Rolf Hilgenfeld

Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases.

PLoS pathogens

Avec: Afzaal M Shareef , Barbara Ludeke , Paul Jordan , Jerome Deval , Rachel Fearns

Helical ordering of envelope-associated proteins and glycoproteins in respiratory syncytial virus.

The EMBO journal

Avec: Michaela J Conley , Judith M Short , Andrew M Burns , James Streetley , Joshua Hutchings , Saskia E Bakker , B Joanne Power , Hussain Jaffery , Joanne Haney , Giulia Zanetti , Pablo R Murcia , Murray Stewart , Rachel Fearns , Swetha Vijayakrishnan , David Bhella

Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcripts.

PLoS pathogens

Avec: Molly R Braun , Sarah L Noton , Emmeline L Blanchard , Afzaal Shareef , Philip J Santangelo , W Evan Johnson , Rachel Fearns

Polymerase-tagged respiratory syncytial virus reveals a dynamic rearrangement of the ribonucleocapsid complex during infection.

PLoS pathogens

Avec: Emmeline L Blanchard , Molly R Braun , Aaron W Lifland , Barbara Ludeke , Sarah L Noton , Daryll Vanover , Chiara Zurla , Rachel Fearns , Philip J Santangelo

EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model.

PLoS pathogens

Avec: Michael H J Rhodin , Nicole V McAllister , Jonathan Castillo , Sarah L Noton , Rachel Fearns , In Jong Kim , Jianming Yu , Thomas P Blaisdell , Joseph Panarese , Brian C Shook , Yat Sun Or , Bryan Goodwin , Kai Lin

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.

Communications biology

Avec: Xiaodi Yu , Pravien Abeywickrema , Brecht Bonneux , Ishani Behera , Brandon Anson , Edgar Jacoby , Amy Fung , Suraj Adhikary , Anusarka Bhaumik , Rodrigo J Carbajo , Suzanne De Bruyn , Robyn Miller , Aaron Patrick , Quyen Pham , Madison Piassek , Nick Verheyen , Afzaal Shareef , Priscila Sutto-Ortiz , Nina Ysebaert , Herman Van Vlijmen , Tim H M Jonckers , Florence Herschke , Jason S McLellan , Etienne Decroly , Rachel Fearns , Sandrine Grosse , Dirk Roymans , Sujata Sharma , Peter Rigaux , Zhinan Jin

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells.

bioRxiv : the preprint server for biology

Avec: Caiqi Zhao , Wei Wang , Yan Bai , Gaurang Amonkar , Hongmei Mou , Judith Olejnik , Adam J Hume , Elke Mühlberger , Yinshan Fang , Jianwen Que , Rachel Fearns , Xingbin Ai , Paul H Lerou

Structural basis for dimerization of a paramyxovirus polymerase complex.

Nature communications

Avec: Jin Xie , Mohamed Ouizougun-Oubari , Li Wang , Guanglei Zhai , Daitze Wu , Zhaohu Lin , Manfu Wang , Barbara Ludeke , Xiaodong Yan , Tobias Nilsson , Lu Gao , Xinyi Huang , Rachel Fearns , Shuai Chen

Réseau de co-auteurs

Barbara Ludeke 5 collaborations

Elke Mühlberger 4 collaborations

Sarah L Noton 4 collaborations

Judith Olejnik 3 collaborations

Adam J Hume 3 collaborations

Victoria A Kleiner 3 collaborations

Afzaal Shareef 3 collaborations

Julien Lescar 2 collaborations

Caiqi Zhao 2 collaborations

Yan Bai 2 collaborations

Wei Wang 2 collaborations

Hongmei Mou 2 collaborations

Paul H Lerou 2 collaborations

Xingbin Ai 2 collaborations

Tessa N Cressey 2 collaborations

Afzaal M Shareef 2 collaborations

Jason S McLellan 2 collaborations

Brecht Bonneux 2 collaborations

Brandon Anson 2 collaborations

Nick Verheyen 2 collaborations

Nina Ysebaert 2 collaborations

Anusarka Bhaumik 2 collaborations

Aaron Patrick 2 collaborations

Amy Fung 2 collaborations

Priscila Sutto-Ortiz 2 collaborations

Etienne Decroly 2 collaborations

Jerome Deval 2 collaborations

Zhinan Jin 2 collaborations

Dirk Roymans 2 collaborations

Peter Rigaux 2 collaborations

Florence Herschke 2 collaborations

Mohamed Ouizougun-Oubari 2 collaborations

Molly R Braun 2 collaborations

Emmeline L Blanchard 2 collaborations

Philip J Santangelo 2 collaborations

Junhua Pan 1 collaboration

Xinlei Qian 1 collaboration

Simon Lattmann 1 collaboration

Abbas El Sahili 1 collaboration

Tiong Han Yeo 1 collaboration

Huan Jia 1 collaboration

Tessa Cressey 1 collaboration

Sarah Noton 1 collaboration

Marian Kalocsay 1 collaboration

I'ah Donovan-Banfield 1 collaboration

Rachel Milligan 1 collaboration

Sophie Hall 1 collaboration

Tianyi Gao 1 collaboration

Eleanor Murphy 1 collaboration

Jack Li 1 collaboration

Ghada T Shawli 1 collaboration

Julian Hiscox 1 collaboration

Xiaodong Zhuang 1 collaboration

Jane A McKeating 1 collaboration

David A Matthews 1 collaboration

Gaurang M Amonkar 1 collaboration

Nicholas W Lukacs 1 collaboration

Patrick O Byrne 1 collaboration

Fumiaki Aihara 1 collaboration

Yumei Wang 1 collaboration

Anna C Belkina 1 collaboration

Joseph P Mizgerd 1 collaboration

Feng Feng 1 collaboration

Thomas B Kepler 1 collaboration

Sergey Tcherniuk 1 collaboration

Suzanne de Bruyn 1 collaboration

Kim Thys 1 collaboration

Nádia Conceição-Neto 1 collaboration

Marcia Van Ginderen 1 collaboration

Leen Kwanten 1 collaboration

Luc Vranckx 1 collaboration

Elien Peeters 1 collaboration

Ellen Lanckacker 1 collaboration

Jack M Gallup 1 collaboration

Panchan Sitthicharoenchai 1 collaboration

Sarhad Alnajjar 1 collaboration

Mark R Ackermann 1 collaboration

Suraj Adhikari 1 collaboration

Stephen W Mason 1 collaboration

David Lançois 1 collaboration

Jean-François Eléouët 1 collaboration

Anil Koul 1 collaboration

Laure R Deflubé 1 collaboration

Elaine Haddock 1 collaboration

Friederike Feldmann 1 collaboration

Hideki Ebihara 1 collaboration

Thierry O Fischmann 1 collaboration

John A Howe 1 collaboration

Douglas C Beshore 1 collaboration

Michael J Eddins 1 collaboration

Yan Hou 1 collaboration

Todd Mayhood 1 collaboration

Daniel Klein 1 collaboration

Debbie D Nahas 1 collaboration

Bob J Lucas 1 collaboration

He Xi 1 collaboration

Edward Murray 1 collaboration

Daphne Y Ma 1 collaboration

Krista Getty 1 collaboration

Victoria Anne Kleiner 1 collaboration

Athanase Badolo 1 collaboration

Felicity Burt 1 collaboration

Susan Daniel 1 collaboration

Eduardo Samo Gudo 1 collaboration

Margaret Kielian 1 collaboration

Yi Shi 1 collaboration

Albrecht von Brunn 1 collaboration

Susan R Weiss 1 collaboration

Rolf Hilgenfeld 1 collaboration

Paul Jordan 1 collaboration

Michaela J Conley 1 collaboration

Judith M Short 1 collaboration

Andrew M Burns 1 collaboration

James Streetley 1 collaboration

Joshua Hutchings 1 collaboration

Saskia E Bakker 1 collaboration

B Joanne Power 1 collaboration

Hussain Jaffery 1 collaboration

Joanne Haney 1 collaboration

Giulia Zanetti 1 collaboration

Pablo R Murcia 1 collaboration

Murray Stewart 1 collaboration

Swetha Vijayakrishnan 1 collaboration

David Bhella 1 collaboration

W Evan Johnson 1 collaboration

Aaron W Lifland 1 collaboration

Daryll Vanover 1 collaboration

Chiara Zurla 1 collaboration

Michael H J Rhodin 1 collaboration

Nicole V McAllister 1 collaboration

Jonathan Castillo 1 collaboration

In Jong Kim 1 collaboration

Jianming Yu 1 collaboration

Thomas P Blaisdell 1 collaboration

Joseph Panarese 1 collaboration

Brian C Shook 1 collaboration

Yat Sun Or 1 collaboration

Bryan Goodwin 1 collaboration

Kai Lin 1 collaboration

Xiaodi Yu 1 collaboration

Pravien Abeywickrema 1 collaboration

Ishani Behera 1 collaboration

Edgar Jacoby 1 collaboration

Suraj Adhikary 1 collaboration

Rodrigo J Carbajo 1 collaboration

Suzanne De Bruyn 1 collaboration

Robyn Miller 1 collaboration

Quyen Pham 1 collaboration

Madison Piassek 1 collaboration

Herman Van Vlijmen 1 collaboration

Tim H M Jonckers 1 collaboration

Sandrine Grosse 1 collaboration

Sujata Sharma 1 collaboration

Gaurang Amonkar 1 collaboration

Yinshan Fang 1 collaboration

Jianwen Que 1 collaboration

Jin Xie 1 collaboration

Li Wang 1 collaboration

Guanglei Zhai 1 collaboration

Daitze Wu 1 collaboration

Zhaohu Lin 1 collaboration

Manfu Wang 1 collaboration

Xiaodong Yan 1 collaboration

Tobias Nilsson 1 collaboration

Lu Gao 1 collaboration

Xinyi Huang 1 collaboration

Shuai Chen 1 collaboration