Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins.
Adolescent
Amygdala
/ anatomy & histology
Birth Weight
/ physiology
Connectome
Default Mode Network
/ anatomy & histology
Female
Hippocampus
/ anatomy & histology
Humans
Infant, Low Birth Weight
/ physiology
Infant, Newborn
Longitudinal Studies
Magnetic Resonance Imaging
Male
Nerve Net
/ anatomy & histology
Sex Factors
Twins, Monozygotic
birth weight
brain development
magnetic resonance imaging
neurodevelopment
twin designs
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
05
01
2020
revised:
02
08
2020
accepted:
04
08
2020
pubmed:
4
9
2020
medline:
15
12
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
Previous research has shown that the prenatal environment, commonly indexed by birth weight (BW), is a predictor of morphological brain development. We previously showed in monozygotic (MZ) twins associations between BW and brain morphology that were independent of genetics. In the present study, we employed a longitudinal MZ twin design to investigate whether variations in prenatal environment (as indexed by discordance in BW) are associated with resting-state functional connectivity (rs-FC) and with structural connectivity. We focused on the limbic and default mode networks (DMNs), which are key regions for emotion regulation and internally generated thoughts, respectively. One hundred and six healthy adolescent MZ twins (53 pairs; 42% male pairs) followed longitudinally from birth underwent a magnetic resonance imaging session at age 15. Graph theoretical analysis was applied to rs-FC measures. TrackVis was used to determine track count as an indicator of structural connectivity strength. Lower BW twins had less efficient limbic network connectivity as compared to their higher BW co-twin, driven by differences in the efficiency of the right hippocampus and right amygdala. Lower BW male twins had fewer tracks connecting the right hippocampus and right amygdala as compared to their higher BW male co-twin. There were no associations between BW and the DMN. These findings highlight the possible role of unique prenatal environmental influences in the later development of efficient spontaneous limbic network connections within healthy individuals, irrespective of DNA sequence or shared environment.
Identifiants
pubmed: 32881198
doi: 10.1002/hbm.25188
pmc: PMC7670633
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
5228-5239Subventions
Organisme : Canada Research Chair Program
Organisme : CIHR
ID : MOP-106422
Pays : Canada
Organisme : CHU Sainte-Justine-Foundation of Stars
Organisme : Fonds de Recherche du Québec Santé
Organisme : Fonds Québécois de la Recherche sur la Société et la Culture
Organisme : National Health Research Development Program
Organisme : Natural Sciences and Engineering Research Council of Canada
Organisme : Sainte-Justine Hospital Research Center
Organisme : Social Sciences and Humanities Research Council of Canada
Organisme : Université de Montréal
Organisme : Université Laval
Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
J Am Acad Child Adolesc Psychiatry. 2009 Sep;48(9):909-918
pubmed: 19633579
Neuroimage. 2015 Jul 15;115:235-44
pubmed: 25887261
J Res Adolesc. 2018 Mar;28(1):134-149
pubmed: 29460354
Twin Res Hum Genet. 2019 Dec;22(6):475-481
pubmed: 31630700
J Child Psychol Psychiatry. 2014 Dec;55(12):1317-27
pubmed: 24828372
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):16039-44
pubmed: 18843113
Nat Commun. 2018 Aug 1;9(1):3003
pubmed: 30068943
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11366-71
pubmed: 22689983
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jan;4(1):62-71
pubmed: 30316743
J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8
pubmed: 9204677
Twin Res Hum Genet. 2018 Jun;21(3):253-262
pubmed: 29642972
Psychol Med. 2014 Sep;44(12):2617-27
pubmed: 24443874
Nature. 1998 Jun 4;393(6684):440-2
pubmed: 9623998
PLoS One. 2007 Jul 04;2(7):e597
pubmed: 17611629
Neurobiol Dis. 2013 Apr;52:24-37
pubmed: 22426398
Neuroimage Clin. 2016 Aug 10;12:381-8
pubmed: 27622134
Brain Struct Funct. 2009 Oct;213(6):525-33
pubmed: 19565262
Front Neurosci. 2018 May 29;12:367
pubmed: 29896088
Hum Brain Mapp. 2013 Dec;34(12):3247-66
pubmed: 22806915
Hum Brain Mapp. 2019 Oct 1;40(14):4239-4252
pubmed: 31228329
Schizophr Bull. 2014 Mar;40(2):410-9
pubmed: 23419977
Neuroimage. 2018 Jul 15;175:138-149
pubmed: 29614348
Neuroimage Clin. 2019;21:101626
pubmed: 30545688
Pediatrics. 2010 Nov;126(5):e1095-101
pubmed: 20937654
Pediatrics. 2009 Feb;123(2):503-11
pubmed: 19171615
JAMA Psychiatry. 2014 Oct;71(10):1138-47
pubmed: 25133665
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
J Neurosci. 2011 Mar 2;31(9):3261-70
pubmed: 21368038
J Neurosci. 2012 May 9;32(19):6550-60
pubmed: 22573677
PLoS One. 2014 May 06;9(5):e96715
pubmed: 24802625
Biol Psychiatry. 2001 Oct 15;50(8):593-9
pubmed: 11690594
Psychol Bull. 2004 Nov;130(6):989-1013
pubmed: 15535745
Front Hum Neurosci. 2015 Nov 04;9:601
pubmed: 26582983
Cereb Cortex. 2010 Sep;20(9):2122-31
pubmed: 20051363
Pediatrics. 2009 Nov;124(5):e964-72
pubmed: 19858152
BMC Psychiatry. 2016 Jul 29;16:270
pubmed: 27473074
Child Dev. 2008 Sep-Oct;79(5):1444-62
pubmed: 18826535
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Neurosci Biobehav Rev. 2009 Mar;33(3):279-96
pubmed: 18824195
Hum Brain Mapp. 2016 Mar;37(3):1178-93
pubmed: 26859312
PLoS One. 2013 Oct 01;8(10):e75065
pubmed: 24098365
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
J Child Psychol Psychiatry. 2018 Oct;59(10):1036-1043
pubmed: 29999186
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1942-7
pubmed: 19171889
Dev Neurosci. 2015;37(6):489-96
pubmed: 26279175
Hum Brain Mapp. 2017 Apr;38(4):2037-2050
pubmed: 28032437
Nat Rev Neurosci. 2009 Jun;10(6):434-45
pubmed: 19401723
J Abnorm Psychol. 2017 Feb;126(2):244-256
pubmed: 27868421
Twin Res Hum Genet. 2015 Dec;18(6):623-34
pubmed: 26608878
Neuroimage. 2011 Mar 1;55(1):165-75
pubmed: 21134471
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
J Pediatr. 2004 Aug;145(2):242-9
pubmed: 15289777
Transl Psychiatry. 2015 Feb 17;5:e508
pubmed: 25689569
Twin Res Hum Genet. 2020 Feb;23(1):8-15
pubmed: 31983355
Placenta. 2008 Nov;29(11):976-81
pubmed: 18835495
Int J Epidemiol. 2005 Oct;34(5):1089-99
pubmed: 16087687
PLoS One. 2017 Apr 27;12(4):e0176601
pubmed: 28448561
Transl Psychiatry. 2018 Aug 8;8(1):147
pubmed: 30089832
J Clin Pathol. 2008 Dec;61(12):1247-53
pubmed: 18794196
Brain. 2005 Nov;128(Pt 11):2588-96
pubmed: 16123146
Eur Neuropsychopharmacol. 2012 Jun;22(6):419-23
pubmed: 22257439
Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20089-94
pubmed: 23169628
Hum Brain Mapp. 2020 Dec 15;41(18):5228-5239
pubmed: 32881198
J Affect Disord. 2018 Dec 1;241:117-126
pubmed: 30118945
PLoS Comput Biol. 2007 Feb 2;3(2):e17
pubmed: 17274684
World J Biol Psychiatry. 2018 Mar;19(2):119-129
pubmed: 28635541
Front Hum Neurosci. 2018 May 01;12:168
pubmed: 29765312
Twin Res Hum Genet. 2007 Aug;10(4):581-6
pubmed: 17708699
Dev Med Child Neurol. 2015 Oct;57(10):899-918
pubmed: 25914112
Hum Brain Mapp. 2015 Oct;36(10):3959-72
pubmed: 26147340
Neurosci Biobehav Rev. 2017 Jul 28;:
pubmed: 28757456
Psychol Bull. 2017 Apr;143(4):347-383
pubmed: 28191983
Dev Med Child Neurol. 2019 Oct;61(10):1127-1133
pubmed: 30740660
Neuroimage. 2006 Apr 1;30(2):452-61
pubmed: 16326115
J Pediatr. 2016 Nov;178:93-100.e6
pubmed: 27634629