Case series of carbapenemase-producing Enterobacteriaceae osteomyelitis: Feel it in your bones.
Bone
CPE
Carbapenemase
Enterobacteriaceae
Infection
Osteomyelitis
Journal
Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
18
05
2020
revised:
20
07
2020
accepted:
14
08
2020
pubmed:
4
9
2020
medline:
24
6
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
Limited data have been reported regarding osteomyelitis due to carbapenemase-producing Enterobacteriaceae (CPE), including co-infections with extended-spectrum β-lactamase (ESBL)-producing micro-organisms. We conducted a retrospective study in a reference centre for bone and joint infections from 2011 to 2019 among patients infected with CPE. Nine patients (mean age 46.8 ± 16.6 years), including three with infected implants, were identified. Infections were mostly polymicrobial (n = 8/9), including Staphylococcus aureus (n = 6/9). CPE were mainly OXA-48-type, associated with ESBL-producing Enterobacteriaceae (n = 8/9), of which 5/9 isolates were Klebsiella pneumoniae. Control of the infection was achieved in seven cases. CPE osteomyelitides are essentially polymicrobial and fluoroquinolone-resistant infections, highlighting the need for efficient surgery with implant removal.
Identifiants
pubmed: 32882450
pii: S2213-7165(20)30212-5
doi: 10.1016/j.jgar.2020.08.007
pii:
doi:
Substances chimiques
Bacterial Proteins
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-78Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.