Edge plane pyrolytic graphite as a sensing surface for the determination of fluvoxamine in urine samples of obsessive-compulsive disorder patients.
Depression medications
Edge plane pyrolytic graphite electrode
Fluvoxamine
Obsessive-compulsive disorder patients
Urine
Voltammetry
Journal
Biosensors & bioelectronics
ISSN: 1873-4235
Titre abrégé: Biosens Bioelectron
Pays: England
ID NLM: 9001289
Informations de publication
Date de publication:
15 Nov 2020
15 Nov 2020
Historique:
received:
21
05
2020
revised:
27
07
2020
accepted:
30
07
2020
pubmed:
4
9
2020
medline:
15
5
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
There is an increasing demand for fast and sensitive determination of antidepressants in human body fluids because of the present scenario of rising depression cases at the global level. A simple and sensitive voltammetric method using edge plane pyrolytic graphite electrode (EPPGE) as a novel sensor is presented for the determination of antidepressant fluvoxamine in urine and blood plasma samples of obsessive-compulsive disorder (OCD) patients. EPPGE is delineated the first time for this determination. EPPGE exhibited strong electrocatalytic activity and enhanced reduction signal towards the sensing of fluvoxamine. Fluvoxamine gave a well-defined reduction peak at ~ - 670 mV using EPPGE. The fluvoxamine reduction peak current was linear to its concentration in the range 5.00 × 10
Identifiants
pubmed: 32882472
pii: S0956-5663(20)30482-6
doi: 10.1016/j.bios.2020.112489
pii:
doi:
Substances chimiques
Graphite
7782-42-5
Fluvoxamine
O4L1XPO44W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112489Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.